Which drug produces Ocular toxicity?
Chlorpromazine is one of the most common psychotropic agents which can potentially induce numerous and diverse unwanted ocular effects. At high dosages, the drug can commonly cause abnormal pigmentation of the eyelids, interpalpebral conjunctiva, lens, and cornea. It can also cause corneal edema [36].
What does chloroquine do to the eyes?
High doses or long-term use of chloroquine may cause irreversible damage to your retina (the membrane layer inside your eye that helps produce vision). This could progress to permanent vision problems.
What are the side effects of the antimalarial drug?
Possible side effects – dizziness, headache, sleep disturbances (insomnia and vivid dreams) and psychiatric reactions (anxiety, depression, panic attacks and hallucinations). It’s very important to tell your doctor about any previous mental health problems, including mild depression.
Does chloroquine cause retinal damage?
Chloroquine retinopathy, is a form of toxic retinopathy (damage of the retina) caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus erythematosus. This eye toxicity limits long-term use of the drugs.
What medications affect eyesight?
Certain classes of drugs are known to cause eye problems. These include diuretics (water pills), antihistamines, antidepressants, drugs that lower cholesterol, beta-blockers and birth control pills. “Antihistamines often cause a very significant dry-eye syndrome,” Andreoli says.
What is Ocular toxicity?
Ocular toxicity includes inflammation and atrophy of the optic nerve and inner retina, loss of white matter, and gliosis of the occipital and parietal lobes causing various degrees of blindness.
Can hydroxychloroquine cause eye problems?
It is known that some people who take hydroxychloroquine for more than five years and/or in high doses are at increased risk of damage to their retina, the light sensitive layer of cells at the back of the eye. This is known as retinal toxicity or retinopathy.
Does chloroquine cause eye problems?
Hydroxychloroquine (Plaquenil) and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported.
What are the side effects of artesunate?
Common side effects of Artesunate include: Loss of appetite on days 1-2. Dizziness on days 1-2. Nausea on days 1-2….Additional Side Effects of Artesunate can include:
- Hives.
- Rash.
- Hemoglobinuria.
- Seizures.
- Neuropsychiatric reactions.
- Reversible neurologic changes.
Does hydroxychloroquine affect your eyes?
Can hydroxychloroquine affect your vision?
Plaquenil binds to retinal pigment cells, causing adverse changes in vision that occur slowly over time. Objects may start to appear blurry or distorted. In the most serious cases of Plaquenil-induced retinal toxicity, the macula is completely destroyed.
What are the side effects of taking antimalarial medications?
Other ocular side effects include mydriasis (pupil dilation), dry eye, Keratitis sicca, contact lens intolerance, decreased accommodation (focusing ability) and blurred vision, and the risk for angle closure glaucoma as stated above. Antimalarial Medications used for Rheumatological Conditions
Are there any medications that have ocular side effects?
However, certain medications have been found to have definite ocular side effects and may pose a risk to the eye or visual system. The listing that follows discusses these more notable cases. Again, it is not meant to be a complete list of ocular medication side effects.
Are there any drugs that are bad for the retina?
Hydroxychloroquine (Plaquenil) is used to treat malaria, lupus and rheumatoid arthritis. It is a known retinal toxin, and the effects are irreversible. Fortunately, most patients taking this drug do not experience side effects at the dosages usually prescribed.
Can a drug overdose lead to permanent ocular damage?
Medication overdoses, drug–drug interactions but also chronic administration of medications at the recommended doses may lead to ocular toxicity. Recognition of the early signs of eye toxicity, withdrawal of the offending agent and prompt referral to an ophthalmologist may avert permanent ocular damage and vision impairment.
