When does TCR gene rearrangement occur?
Recombination of Tcrd, Tcrg and Tcrb all occur during the CD4−CD8−double-negative (DN) 2 (CD44+CD25−) and DN3 (CD44−CD25+) stages of thymocyte development, during an initial period of recombinase expression.
What is TCR rearrangement?
T cell receptor (TCR) gene rearrangement is an important event in T cell ontogeny that enables T cells to recognise antigens specifically, and any dysregulation in this complex yet highly regulated process may result in disease.
What is a TCR test?
A laboratory test in which cells in a sample of blood or bone marrow are checked to see if there are certain changes in the genes that make receptors on T cells (white blood cells).
Why is TCR test done?
This test detects characteristic changes (rearrangements) in specific genes in T-cells. This information can be helpful in diagnosing a T-cell lymphoma.
What is TCR gene?
The T-cell receptor (TCR) is a protein complex found on the surface of T cells, or T lymphocytes, that is responsible for recognizing fragments of antigen as peptides bound to major histocompatibility complex (MHC) molecules.
When does VDJ recombination occur?
G1 phase
V(D)J recombination may preferentially occur in G1 phase of the cell cycle. Recent experiments with antibodies against murine RAG2 indicate that RAG2 protein is 20-fold more abundant in G1 cell cycle phase than in S, G2, or M for either pre-B cells or thymocytes (Lin and Desiderio, 1994).
What is TCR?
A group of proteins found on T cells (a type of immune cell that recognizes and binds to foreign substances). TCRs bind to certain antigens (proteins) found on abnormal cells, cancer cells, cells from other organisms, and cells infected with a virus or another microorganism. Also called T-cell receptor.
How is TCR diversity generated?
TCR diversity is generated by the random and imprecise rearrangements of the V and J segments of the TCR alpha (TCRA) and V, D, and J segments of the TCR beta (TCRB) genes in the thymus. Thymic production of T cells is the sole mechanism to generate TCR diversity.
What is the meaning of TCR?
T-cell receptor
Abbreviation for T-cell receptor.
What is clonal TCR?
Clonal expansions of T cells carrying identical T-cell-receptor (TCR) genes are the hallmark of T-cell malignancies, but they can also result from a strong immune reaction to a dominant epitope. The basis for the molecular detection of clonal T cells is amplification of the V-(D)-N-J region of the TCR gene.
What does TCR stand for?
TCR
| Acronym | Definition |
|---|---|
| TCR | Teachers College Record |
| TCR | The Climate Registry |
| TCR | Temperature Coefficient of Resistance |
| TCR | Total Capital Ratio (finance) |
What is the diagnostic significance of TCR gene rearrangement?
In this study, we used polymerase chain reaction (PCR) to investigate the diagnostic significance of detecting TCR-γ and -β gene clonal rearrangement in the early diagnosis of mycosis fungoides. PCR for TCR-γ and TCR-β gene rearrangement was performed on 19 patients with suspected early MF, 6 with typical MF, and 6 with chronic dermatitis.
How are gene rearrangement tests used to diagnose lymphoma?
This test detects characteristic changes (rearrangements) in specific genes in T-cells. This information can be helpful in diagnosing a T-cell lymphoma. T-cells are a type of lymphocyte (a kind of white blood cell, WBC) that helps to protect the body from infection.
Can a T cell receptor gene rearrangement cause cancer?
The detection of a clonal T-cell receptor gene rearrangement is not synonymous with the presence of T-cell lymphoma. An individual may have a clonal T-cell population and not have cancer.
Can a negative T cell receptor test result in lymphoma?
A negative result on this test does not necessarily rule out a lymphoma. A person with a negative result for a clonal T-cell receptor gene rearrangement may still have lymphoma.
