What snakes does CroFab cover?
CroFab is composed of several monovalent Fragment antigen-binding proteins (Fab) derived from the blood of sheep immunized with one of four snake venom: Crotalus atrox (western diamondback rattlesnake), Crotalus adamanteus (Eastern diamondback rattlesnake), Crotalus scutulatus (Mojave rattlesnake), or Agkistrodon …
What snakes does Anavip cover?
ANAVIP is now indicated for all North American Pit Viper envenomations 1
- Phase 3 study enrolled 99 Rattlesnake or Unknown Pit Viper bites, 21 Copperhead bites, and 1 Cottonmouth bite 2,3
- ANAVIP controlled local, systemic, and hematologic symptoms for all patients studied 2
Which is correct antivenin or antivenom?
Antivenom is also known as antivenin (sometimes pronounced “antiveneen”). Although many of us who have been in the business a long time still use the old term, the more common word these days is antivenom, the English version.
When should I give Crofab?
Dose. Administer CROFAB as soon as possible in patients who develop any signs of envenomation (e.g., local injury, coagulation abnormality or systemic signs of envenomation) to prevent clinical deterioration. CROFAB was shown in clinical studies to be effective when given within 6 hours of snakebite.
Is Crofab an antivenom?
CroFab® is the result of manufacturing 4 separate monospecific antivenoms that are mixed at the end to create an antivenom that is effective against the venoms of all North American pit vipers. Each component “antivenom” uses venom from 1 snake type, 1 flock of sheep, and its own affinity purification column.
How does Crofab work?
CROFAB is a venom-specific Fab fragment of immunoglobulin G (IgG) that works by binding and neutralizing venom toxins, facilitating their redistribution away from target tissues and their elimination from the body.
What is Anavip made of?
ANAVIP is made from equine (horse) plasma and may therefore carry a risk of transmitting infectious agents, e.g., viruses. Trace amounts of cresol from the manufacturing process are contained in ANAVIP. Localized reactions and generalized myalgias have been reported with the use of cresol as an injectable excipient.
How do you give CroFab?
Mix 4-6 vials‡ of CroFab® in 250 mL normal saline (0.9% sodium chloride) Infuse over 60 minutes, proceeding slowly over the first 10 minutes at a 25- to 50-mL/hour rate with careful observation for any allergic reaction. If no allergic reaction occurs, increase infusion rate to the full 250 mL/hour until completion.
Why is it antivenin and not antivenom?
Both “antivenene” and “antivenin” were used as nouns from their first appearance, sometimes as a contraction of “antivenom serum,” and they were never hyphenated. A more general contraction was “anti-serum” or “antiserum,” which could refer to antivenin or to an antitoxin for infectious disease.
What is CroFab used for?
CROFAB is indicated for the management of adult and pediatric patients with North American crotalid envenomation. The term crotalid is used to describe the Crotalinae subfamily (formerly known as Crotalidae) of venomous snakes which includes rattlesnakes, copperheads and cottonmouths/water moccasins.
Which is a better antivenom ANAVIP or CroFab?
Anavip is a F(ab’)2 fragment with two venom binding sites, compared to a CroFab which is a single Fab fragment with one venom binding site (see Figure 1). The F(ab’)2 confers a longer elimination half-life, and therefore is proposed to require less re-dosing than the single Fab antivenom.
When did the FDA approve CroFab for snakebite?
After being approved by the Food and Drug Administration (FDA) in 2000, CroFab was the only commercially available snake antivenin in the United States.
How much is the new snakebite drug ANAVIP?
CroFab generated more than $132 million in revenue for BTG, according to the company’s 2019 annual report. It represented 14% of total revenue. Anavip, the competitor drug that was launched in October, is priced at $1,220 per vial for wholesalers, and the recommended initial dose is 10 vials.
Which is the best antivenom for Crotalid envenomation?
CroFab is the most widely available antivenom used in the treatment of North American Crotalid envenomations. In 2015, Anavip was FDA approved, but was not released for distribution until 2018.
