What should be done in case of extravasation of vesicant?
Treatment of a vesicant extravasation includes immediate cessation of infusion, aspiration of as much extravasated drug as possible through the still-intact catheter, and attempts for the aspiration of the extravasated agent in the surrounding tissue. This aspiration may help to limit the extent of tissue damage.
Is trabectedin a vesicant?
Optimizing safety in outpatient administration of trabectedin, a novel anticancer vesicant drug via continuous intravenous infusion.
How do you treat vincristine extravasation?
Conclusions: Topical dimethyl sulfoxide four times daily for 14 days plus subcutaneous chondroitinsulfatase in one or two applications effectively treated an extravasation of both doxorubicin and vincristine in our patient.
What is the first treatment for extravasation?
At the first sign of extravasation, the following steps are recommended: (1) stop administration of IV fluids immediately, (2) disconnect the IV tube from the cannula, (3) aspirate any residual drug from the cannula, (4) administer a drug-specific antidote, and (5) notify the physician (Fig. 1).
Is carboplatin a vesicant?
Carboplatin is a platinum chemotherapeutic agent commonly used in veterinary oncology that is currently classified as an irritant to local tissues when extravasated. To the authors’ knowledge, there are no reports of vesicant injuries associated with carboplatin administration reported in the veterinary literature.
What happens if IV potassium infiltration?
When left unchecked and untreated, IV infiltration can result in pain, swelling, compartment syndrome, and even amputation of the affected limb.
What is the best method of extravasation prevention?
Elevate the affected arm. Apply either ice packs or warm compresses to the affected area, depending on the type of vesicant. For most extravasations, apply ice for 20 minutes four to six times a day for 24 to 48 hours.
What happens during extravasation?
Extravasation occurs when a vesicant drug leaks out of the vein and into the surrounding tissue. When this happens, a person will likely experience serious tissue damage, including ulceration and tissue death, if they do not receive treatment in time.
How can we reduce extravasation?
Some possible treatments are:
- Elevate the site as much as possible to help reduce swelling.
- Apply a warm or cold compress (depending on the fluid) for 30 minutes every 2-3 hours to help reduce swelling and discomfort.
- Medication-If recommended, medicine for extravasations is given within 24 hours for best effect.
Is Cytoxan a vesicant?
Alkylating agents like cyclophosphamide, ifosfamide and andmelphalan are considered neutrals[16]. Although etoposide and teniposideare usually classified as irritants, they may have low vesicant potential if a highly concentrated infused drug is extravasated[9].
