What kind of antibody is etanercept?
Infliximab is a humanized mouse monoclonal antibody, adalimumab a fully human monoclonal antibody, and etanercept a construct comprising two human p75 TNF-α receptors coupled to the Fc portion of a monoclonal human antibody.
Is etanercept an anti TNF?
Etanercept is a type of drug known as a biological therapy. In rheumatoid arthritis and some other inflammatory conditions, too much of a protein called TNF is produced by the immune system. This causes inflammation, pain and damage to your joints. Anti-TNF drugs, such as etanercept, block TNF and reduce inflammation.
What is the structure of etanercept?
Structure. Etanercept is made from the combination of two naturally occurring soluble human 75-kilodalton TNF receptors linked to an Fc portion of an IgG1. The effect is an artificially engineered dimeric fusion protein.
What is Fc fusion protein?
Fc-fusion proteins are bioengineered polypeptides that join the crystallizable fragment (Fc) domain of an antibody with another biologically active protein domain or peptide to generate a molecule with unique structure–function properties and significant therapeutic potential.
Where is etanercept metabolized?
After binding to TNFα, the etanercept-TNF complex is probably metabolized by proteolytic processes, before recycling or elimination in the urine or bile (Zhou 2005). The steady-state concentration-time profile is similar for 50 mg once-weekly and 25 mg twice-weekly administration (Nestorov et al 2004).
What is etanercept injection?
Etanercept is a drug that reduces the signs and symptoms of moderate to severe rheumatoid arthritis (RA), such as joint swelling, pain, fatigue, and length of morning stiffness. It is also prescribed for psoriasis, psoriatic arthritis, ankylosing spondylitis, and juvenile idiopathic arthritis.
What is Enbrel used to treat?
Enbrel and Humira are both brand-name medications that are approved to treat: moderate to severe plaque psoriasis. psoriatic arthritis. rheumatoid arthritis.
Is etanercept a Dmard?
Background: Etanercept is a soluble tumour necrosis factor alpha-receptor disease-modifying anti-rheumatic drug (DMARD) for the treatment of rheumatoid arthritis (RA).
What is the Fc tag?
Fc-tag Basics IgG-Fc tag is the constant region (domain 3 and 4) of immunoglobulin heavy-chain. It is fused to the C-terminus of a protein and hence it recembles a mouse/human chimeric antibody in a way, and sometimes the Fc-fusion protein is also called Fc chimeric protein. The Fc-tag is about 25 KDa.
How is etanercept metabolized?
It is slowly cleared from the body with an elimination half-life of 70 hours (30–300) in patients with RA. After binding to TNFα, the etanercept-TNF complex is probably metabolized by proteolytic processes, before recycling or elimination in the urine or bile (Zhou 2005).
