What is the shelf life of midazolam?
Midazolam hydrochloride is available as 1 mg/ml and 5 mg/ml injections for IM or IV administration. These products are very stable with a shelf-life of 36 months.
Can midazolam be stored in plastic?
Midazolam hydrochloride, when stored in its undiluted form in disposable plastic syringes at 24– 26 °C, did not change color or form a precipitate during the 36-day study. The pH of the drug solution (pH 3) did not change. There was <1% drug loss in all the midazolam solu- tions (Table 1).
How do you store midazolam?
Storage of midazolam The midazolam should be stored in a cool cupboard, safely out of the reach of children. Each bottle of midazolam has its own shelf life of 2 years. Any medicine that is out of date should not be used.
Should midazolam be refrigerated?
If stored under refrigerated conditions, such solutions can retain more than 90% midazolam for up to 7 days following preparation. Even at temperatures that may be encountered during use (22°–38°C), such solutions will retain more than 90% midazolam for up to 4 days.
Where do you inject midazolam?
This medication is given by slow injection into a vein or muscle as directed by your doctor. It is usually given by a health care professional.
How long is midazolam stable in a syringe?
36 days
Conclusion. Midazolam 5 mg/mL (as the hydro- chloride salt) in polypropylene syringes stored in the dark was stable for 36 days at 24–26 °C.
What is the shelf life of prefilled syringes of midazolam?
2 years. Keep the pre-filled syringe in the outer carton in order to protect from light.
How do you administer midazolam injection?
The intravenous injection of midazolam should be given slowly, at a rate of approx. 1 mg/30 seconds. In adults below the age of 60 the initial dose is 2 to 2.5 mg given 5 to 10 minutes before the beginning of the procedure. Further doses of 1 mg may be given as necessary.
Can you freeze midazolam?
The evaluated 1-mg/mL midazolam solution was stable over a 1-year period when stored at a refrigerated (5°C) or frozen (–20°C) temperature in both vials and syringes; with storage at 25°C, the stability duration was lower.
How do you dilute midazolam injections?
Both the 1 mg/mL and 5 mg/mL formulations of midazolam may be diluted with 0.9% sodium chloride or 5% dextrose in water.
Do you dilute midazolam?
For continuous infusion, midazolam 5 mg/mL formulation is recommended diluted to a concentration of 0.5 mg/mL with 0.9% sodium chloride or 5% dextrose in water.
How is the stability of midazolam hydrochloride injection evaluated?
The stability of midazolam hydrochloride injection 1-mg/mL solutions in polyvinyl chloride (PVC) and polyolefin bags under varying conditions was evaluated. Triplicate solutions of midazolam hydrochloride 1-mg/mL were prepared in polyolefin and PVC i.v. bags by diluting midazolam hydrochloride injection 5 mg/mL with 5% dextrose injection.
How long does the sterility of midazolam last?
Sterility after 28 days was retained. Midazolam hydrochloride 1-mg/mL solutions diluted in 5% dextrose injection remained stable over 27 days in both polyolefin and PVC i.v. bags, regardless of storage condition.
Why is 1 mg of midazolam in a PVC bag?
The solutions in PVC bags contained lower initial concentrations, most likely due to overfill in the prefilled PVC bags, resulting in an approximate reduction in drug concentration of 0.1 mg/mL.
