What is the process of long bone growth?

Long bones grow on a template of cartilage, in a process called endochondral ossification. Initially, the mesenchymal condensations differentiate into cartilage, populated by cells called the chondrocytes. The template then condenses and becomes hypoxic in the middle. it’s called the cartilage growth plate.

What is the process of long bone growth and remodeling?

Throughout life, bone is constantly being replaced in the process of bone remodeling. In this process, osteoclasts resorb bone, and osteoblasts make new bone to replace it. Bone remodeling shapes the skeleton, repairs tiny flaws in bones, and helps maintain mineral homeostasis in the blood.

What is the process of bone development?

The process of bone formation is called osteogenesis or ossification. After progenitor cells form osteoblastic lines, they proceed with three stages of development of cell differentiation, called proliferation, maturation of matrix, and mineralization.

What process allows long bones to grow?

Bones grow in length at the epiphyseal plate by a process that is similar to endochondral ossification. The cartilage in the region of the epiphyseal plate next to the epiphysis continues to grow by mitosis.

How do long bones grow in width and length?

Long bones lengthen at the epiphyseal plate with the addition of bone tissue and increase in width by a process called appositional growth.

How do long bones grow in length?

Bones grow in length at the epiphyseal plate by a process that is similar to endochondral ossification. The cartilage in the region of the epiphyseal plate next to the epiphysis continues to grow by mitosis. The chondrocytes, in the region next to the diaphysis, age and degenerate.

What are the 4 stages of bone remodeling?

Bone turnover rates differ depending on the bone and the area within the bone. There are four stages in the repair of a broken bone: 1) the formation of hematoma at the break, 2) the formation of a fibrocartilaginous callus, 3) the formation of a bony callus, and 4) remodeling and addition of compact bone.

What are the steps in bone repair?

There are four stages in the repair of a broken bone: 1) the formation of hematoma at the break, 2) the formation of a fibrocartilaginous callus, 3) the formation of a bony callus, and 4) remodeling and addition of compact bone.

How do bones grow in length and diameter?

In endochondral ossification, bone develops by replacing hyaline cartilage. Activity in the epiphyseal plate enables bones to grow in length (this is interstitial growth). Appositional growth allows bones to grow in diameter. Remodeling occurs as bone is resorbed and replaced by new bone.

Where do long bones come from?

Bones at the base of the skull and long bones form via endochondral ossification. In a long bone, for example, at about 6 to 8 weeks after conception, some of the mesenchymal cells differentiate into chondroblasts (cartilage cells) that form the hyaline cartilaginous skeletal precursor of the bones (Figure 6.4.

How does a long bone grow in width?

When does a bone cease to grow in length?

When a bone ceases to grow in length at about ages 14–24, the cartilage in the epiphyseal plate is replaced by bone; the resulting bony structure is known as the epiphyseal line. The articular cartilage is a thin layer of hyaline cartilage covering the part of the epiphysis where the bone forms an articulation (joint) with another bone.

What is the process of bone growth and development?

Bone Growth and Development. Ossification, or osteogenesis, is the process of bone formation by osteoblasts. Ossification is distinct from the process of calcification; whereas calcification takes place during the ossification of bones, it can also occur in other tissues.

Where does the ossification of the diaphysis take place?

Endochondral Ossification. At the same time, the cartilage in the center of the diaphysis begins to disintegrate. Osteoblasts penetrate the disintegrating cartilage and replace it with spongy bone. This forms a primary ossification center. Ossification continues from this center toward the ends of the bones.

How does endochondral ossification contribute to bone growth?

Endochondral ossification is the process of bone development from hyaline cartilage. Long bones lengthen as chondrocytes divide and secrete hyaline cartilage. Osteoblasts replace cartilage with bone. Appositional growth is the increase in the diameter of bones by the addition of bone tissue at the surface of bones.