What is the function of marginal zone?

Function. The major role of marginal zone is to trap particulate antigen from the circulation and present the antigen to the lymphocytes of the spleen. Experiments have shown that inert latex beads as well as live bacteria such as Escherichia coli and Listeria monocytogenes are trapped by the marginal zone.

What is splenic marginal zone?

Splenic marginal zone lymphoma (SMZL) is a low-grade B-cell non-Hodgkin’s lymphoma characterized by massive splenomegaly, moderate lymphocytosis with or without villous lymphocytes, rare involvement of peripheral lymph nodes and indolent clinical course.

What cells are in the marginal zone of the spleen?

The marginal zone is described as a layer surrounding the periarteriolar lymphocyte sheath (PALS) and B cell follicles, predominantly composed of intermediate-sized lymphocytes.

What is the function of the spleen in the body?

The physical organization of the spleen allows it to filter blood of pathogens and abnormal cells and facilitate … The spleen is the largest secondary lymphoid organ in the body and, as such, hosts a wide range of immunologic functions alongside its roles in hematopoiesis and red blood cell clearance.

What is the function of Myoepithelial cells in the spleen?

Both the capsule and trabeculae contain myoepithelial cells which have the ability to contract. As the spleen stores a significant amount of blood, the contraction of myoepithelial cells pumps stored blood into the circulatory system when the body is in need; for example during intense physical activity or massive hemorrhage.

How are white blood cells broken down in the spleen?

Blood cells that can’t pass the test will be broken down in your spleen by macrophages. Macrophages are large white blood cells that specialize in destroying these unhealthy red blood cells. Always economical, your spleen saves any useful components from the old cells, such as iron.

What does the spleen save from the bone marrow?

Always economical, your spleen saves any useful components from the old cells, such as iron. It stores iron in the form of ferritin or bilirubin, and eventually returns the iron to your bone marrow, where hemoglobin is made.