What is the function of Listeriolysin?
Listeriolysin O (LLO) is a secreted pore-forming protein essential for the escape of L. monocytogenes from the vacuole formed upon initial internalization. However, its role in intracellular growth and cell-to-cell spread events has not been testable by a genetic approach.
What type of toxin is Listeriolysin?
Listeriolysin O (LLO) is a cholesterol-dependent pore-forming toxin produced by the bacterium to disrupt vacuolar membranes and promote bacterial entry into the cytosol [48].
What do Internalin related proteins do?
The listerial protein internalin (InlA) mediates bacterial adhesion and invasion of epithelial cells in the human intestine through specific interaction with its host cell receptor E-cadherin.
Does Listeria monocytogenes produce a toxin?
Listeria monocytogenes is a foodborne pathogen capable of secreting listeriolysin O (LLO), a pore-forming toxin encoded by the hly gene.
What is granulomatosis Infantiseptica?
Granulomatosis infantiseptica is an intrauterine infection with a high fetal or neonatal mortality but a very low mortality for the mother.
Is Listeriolysin o an exotoxin?
The present study investigated the role of the listerial exotoxins listeriolysin (LLO) and phosphatidylinositol-specific phospholipase C (PlcA) in human neutrophil activation. Different Listeria strains, mutated in individual virulence genes, as well as purified LLO were used.
What is the function of E cadherin?
E-cadherin is involved in the maintenance and the homeostasis of the normal adult epithelial tissue structure and integrity (van Roy and Berx 2008). As previously mentioned, its function lies primarily in the formation of adherens junctions.
What is the disease Listeria?
Listeriosis is a serious infection caused by the germ Listeria monocytogenes. People usually become ill with listeriosis after eating contaminated food. The disease primarily affects pregnant women, newborns, older adults, and people with weakened immune systems.
Is Listeriolysin an exotoxin?
Role of Listeria monocytogenes exotoxins listeriolysin and phosphatidylinositol-specific phospholipase C in activation of human neutrophils. Infect Immun.
What organs does listeriosis affect?
Listeriosis is an infection caused by the bacteria Listeria monocytogenes. People become infected by eating foods contaminated with the bacteria. Listeria may infect many different sites in the body, such as the brain, spinal cord membranes, or the bloodstream.
Can listeriosis be cured?
Most normal people spontaneously clear the infection and require no treatment. In contrast, health care professionals should treat people with risk factors quickly with IV antibiotics. Ingesting contaminated food or fluid exposes people to Listeria bacteria.
What are the toxins produced by Listeria monocytogenes?
Listeriolysin O
Listeriolysin O (LLO) is a toxin produced by Listeria monocytogenes, an opportunistic bacterial pathogen responsible for the disease listeriosis. This disease starts with the ingestion of contaminated foods and mainly affects immunocompromised individuals, newborns, and pregnant women.
