What is the example of partition coefficient?

If one of the solvents is a gas and the other a liquid, a gas/liquid partition coefficient can be determined. For example, the blood/gas partition coefficient of a general anesthetic measures how easily the anesthetic passes from gas to blood.

What is the formula for partition coefficient?

A partition coefficient is the ratio of the concentration of a substance in one medium or phase (C1) to the concentration in a second phase (C2) when the two concentrations are at equilibrium; that is, partition coefficient = (C1/C2)equil. The units of C1 and C2 may be different.

How do you find the partition coefficient of an experiment?

The partition coefficient of a drug may be determined by shaking it with equal parts of two immiscible solvents (the organic layer, which is saturated with water, and the aqueous drug solution) until equilibrium is attained. The content of the drug in one of the layers is determined and the value is calculated.

What is its relation with partition coefficient KD?

Thus, Kd (a partition coefficient) is a ratio of solid phase to solute concentrations. Often Kd values are determined over a range of concentrations at a constant temperature.

What is the lipid water partition coefficient?

Lipid/Water Partition Coefficient: Introduction The lipid/water partition coefficient denotes the ratio of the concentration of a drug in two immiscible or slightly miscible phases.

What does a small partition coefficient mean?

permeability of cell membranes unit of measure called the partition coefficient. The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.

What does partition coefficient tell you?

a. Partition Coefficient. The partition coefficient is the measure of the lipophilicity of a drug and an indication of its ability to cross the cell membrane. It is defined as the ratio between un-ionized drug distributed between the organic and aqueous layers at equilibrium.

What is KD in water?

Soil adsorption coefficient (Kd) measures the amount of chemical substance adsorbed onto soil per amount of water. It is also known as Freundlich solid-water distribution coefficients (Kf). Kd or Kf= Concentration of chemical in soil/Concentration of chemical substance in water.