What is Thallium-201 used for in medicine?
Thallous chloride Tl 201 injection is used in adults to help diagnose heart disease (eg, coronary artery disease, heart attack). It is used in certain procedures called planar scintigraphy or single-photon emission computed tomography (SPECT).
What does thallium-201 scan mean?
Thallium-201 is a radiopharmaceutical used in myocardial perfusion imaging (MPI) using either planar or single photon emission computed tomography (SPECT) techniques for the diagnosis and localization of myocardial infarction.
When is Thallium-201 used?
Thallium-201 is a radiopharmaceutical agent used in the diagnosis of coronary artery disease and parathyroid hyperactivity.
How is Thallium-201 injected?
Thallium-201 (201Tl) is the conventional perfusion tracer [4]. Tl behaves like a potassium analog and enters the myocytes through Na+/K+ ATPase channels. Tl is injected intravenously at peak exercise or during pharmacological stress and imaging is started soon after completion of stress.
Is Thallium 201 toxic?
The radioisotope thallium-201 (as the soluble chloride TlCl) is used in small amounts as an agent in a nuclear medicine scan, during one type of nuclear cardiac stress test. Soluble thallium salts (many of which are nearly tasteless) are highly toxic, and they were historically used in rat poisons and insecticides.
What happens when Thallium 201 enters the body?
The radioactive isotope thallium 201 behaves physiologically as a potassium analog, and when injected intravenously accumulates rapidly within the cells of many organs. Uptake of the isotope reflects both regional perfusion and sodium-potassium pump activity.
Is Thallium-201 toxic?
Is Thallium-201 radioactive?
“Radioactive Thallium-201, usually in the form of the chloride – is used as a cardiac imaging agent. It’s a radioactive isotope with a half life of a little over 3 days so it disappears pretty fast. It’s a gamma emitter which guarantees that the radioactivity is visible outside the body.
Is thallium still used in rat poison?
Thallium was used historically as a rodenticide, but has since been banned in the United States due to its toxicity from accidental exposure.
What happens when thallium 201 enters the body?
Is Thallium 201 radioactive?
What is the significance of 201 TL SPECT?
Many authors have investigated 201 Tl SPECT for determining tumor grade. 11–18 Uptake of 201 Tl generally correlates with histological tumor grade, however there is considerable overlap between tumor types.
What is the half life of thallium Tl-201?
Thallium-201 is the radioactive isotope of thallium with relative atomic mass 200.9708 and half-life of 72.912 hours. Thallium Tl-201 is under investigation in clinical trial NCT02697760 (The CZT Dynamic Myocardial Perfusion Imaging).
What does lack of Tl-201 mean in a tumor?
The lack of Tl-201 uptake in a mass indicates tumor necrosis, and tumor response results in decreasing Tl-201 uptake. Tl-201 is superior to both Tc-99m MDP and Ga-67 for imaging of bone and soft tissue tumors.
What is thallous chloride TL 201 used for?
Thallous Chloride Tl 201 is indicated also for the localization of sites of parathyroid hyperactivity in patients with elevated serum calcium and parathyroid hormone levels. It may also be useful in pre-operative screening to localize extrathyroidal and mediastinal sites of parathyroid hyperactivity and for postsurgical reexamination.
