What is psoriasis pathogenesis?

It has been hypothesized that the disease starts with the activation of T cell by an unknown antigen, which leads to secretion of an array of cytokines by activated T cells, inflammatory cells, and keratinocytes. The characteristic lesion of psoriasis is due to the hyper-proliferation of the keratinocyte.

What plays a role in the etiology of psoriasis?

Etiology of Psoriasis The cause of psoriasis is unclear but involves immune stimulation of epidermal keratinocytes; T cells seem to play a central role. Family history is common, and certain genes and human leukocyte antigens (Cw6, B13, B17) are associated with psoriasis.

What is the mechanism of psoriasis?

Psoriasis is a polygenic, chronic relapsing inflammatory autoimmune disease based on an interplay between antigen-presenting dendritic cells, T cells and keratinocytes creating the typical signature skin lesions, that is sharply demarcated reddish and scaly plaques.

What is psoriasis article?

Psoriasis is a chronic proliferative and inflammatory condition of the skin. It is characterized by erythematous plaques covered with silvery scales particularly over the extensor surfaces, scalp, and lumbosacral region.

What causes psoriasis according to Ayurveda?

Ayurvedic specialists believe psoriasis results from unbalanced vata and kapha doshas. They think that toxins, stress, and too much of certain foods, like yogurt, seafood, and salty food, also can be to blame.

What proteins cause psoriasis?

Prostanoids and leukotrienes (LTs) are the main lipid mediators derived from arachidonic acid, and might promote psoriasis [13].

What is psoriasis epidemiology?

Psoriasis affects approximately 125 million people globally, which is about 2.2% of the worldwide population. The prevalence varies in different areas of the world; however, higher rates are reported in developed countries accounting for 4.6% of the population.

What is definitive diagnosis of psoriasis?

Skin Biopsy Most of the time, your dermatologist can diagnose psoriasis just by examining your skin. But if he or she needs more information to confirm the diagnosis and rule out other causes of symptoms, such as eczema or cutaneous lupus, a skin biopsy may be performed.

What is psoriasis according to Ayurveda?

According to Ayurveda, Psoriasis (Kitibh Kust) occurs due to vitiation of Vata, Kapha, Pitta & Rakta doshas. The intake of Incompatible Food, Accumulation of Toxins etc. considered as the two of the basic energies/humors, for maintaining our body equilibrium.

Is psoriasis caused by a pathogen?

The most common cause of psoriasis and bad health generally is probably the bacterial overgrowth in the intestines and root canal teeth. Along with the others very pathogenic bacteria the two common types of bacteria that can live in the body are the Streptococcus and Staphylococcus species.

What is the main cause of psoriasis?

While the exact cause of psoriasis is unknown, it’s an autoimmune condition in which a faulty immune system changes the life cycle of skin cells in the body. This change causes the cells to build up rapidly on the surface of the skin in just a few days.

Do genetics cause psoriasis?

Scientists working on the genetic causes of psoriasis start by assuming that the condition results from a malfunction of the immune system . Research on psoriatic Psoriasis A chronic skin disease which results in scaly, often itchy areas in patches. skin shows that it contains large numbers of immune cells that produce inflammatory molecules known as cytokines.

Is psoriasis a cutaneous disease or systemic disease?

The traditional belief about psoriasis is that it is a cutaneous disease without visceral involvements, albeit 10-30% of the patients have joint involvements. This concept is challenged in recent few years when more and more systemic co-morbidities had been reported. When the term “psoriasis and co-morbidities” is searched in