What is HGS drug?
HGS-TR2J is a novel agonistic human monoclonal antibody to TRAIL Receptor 2, in patients with advanced solid malignancies. It is developed by Human Genome Sciences, Inc and is under Phase I of clinical trial.
What happened to Human Genome Sciences?
After a tedious game of playing hard to get, Human Genome Sciences has finally fallen into the arms of partner GlaxoSmithKline, which will pay $14.25 a share or $3 billion, including cash and debt, $1.25 more per share and $400 million more in total than GSK’s offered back in April.
Who bought Hgsi?
GlaxoSmithKline plc (LSE: GSK) today announced that it has completed its acquisition of Human Genome Sciences (NASDAQ: HGSI) for US$3.6 billion on an equity basis, or approximately US$3 billion net of cash and debt. All outstanding shares of HGS were acquired for US$14.25 per share in cash.
Who owns the human genome?
NHGRI, an agency of the National Institutes of Health, works with the Joint Genome Institute of the U.S. Department of Energy in coordinating the U.S. portion of the HGP, a 15-year program funded by the government and nonprofit foundations.
Why do geneticists like to turn genes off?
Gene regulation is an important part of normal development. Genes are turned on and off in different patterns during development to make a brain cell look and act different from a liver cell or a muscle cell, for example. Gene regulation also allows cells to react quickly to changes in their environments.
Which is bigger gene or genome?
From smallest to largest: nucleotide, gene, chromosome, genome. A chromosome contains many genes. The genome is all the DNA of a particular organism. All of an organism’s chromosomes compose the organism’s genome.
How many DNA series does a human have?
The diploid human genome is thus composed of 46 DNA molecules of 24 distinct types. Because human chromosomes exist in pairs that are almost identical, only 3 billion nucleotide pairs (the haploid genome) need to be sequenced to gain complete information concerning a representative human genome.
How do you silence a gene?
The genes can be silenced by siRNA molecules that cause the endonucleatic cleavage of the target mRNA molecules or by miRNA molecules that suppress translation of the mRNA molecule. With the cleavage or translational repression of the mRNA molecules, the genes that form them are rendered essentially inactive.
How does a gene get turned on?
Activation of a gene—transcription—is kicked off when proteins called transcription factors bind to two key bits of DNA, an enhancer and a promoter. The study found that the enhancer and the promoter have to practically touch in order to kick off transcription.
Is DNA a gene?
A gene is the basic physical and functional unit of heredity. Genes are made up of DNA. Some genes act as instructions to make molecules called proteins.
Are humans 99.9 percent the same?
All human beings are 99.9 percent identical in their genetic makeup. Differences in the remaining 0.1 percent hold important clues about the causes of diseases. All human beings are 99.9 percent identical in their genetic makeup.
Is gene silencing permanent?
The important distinction between gene therapy / genome editing and gene silencing treatments are that the former, by acting to correct the underlying genetic defect, are a form of semi-permanent or (ideally) permanent cure, whereas gene silencing is a lifelong treatment for a disease.
