What is HBME 1?

Clinical Information. This mesothelial cell (HBME-1) antibody stains an unknown antigen in the microvillous processes of mesothelial cells with a “thick membrane” staining pattern.

What is the role of immunohistochemical studies in differentiating malignant thyroid neoplasms?

Immunohistochemical stain reveals that the tumor cells of classic papillary thyroid carcinoma are strongly and diffusely positive for Ret oncoprotein (100×). Immunohistochemical stain reveals that the tumor cells of classic papillary thyroid carcinoma are strongly and diffusely positive for HBME-1 (100×).

What is CK19 positive?

CK19 is positive in the most of neuroendocrine tumors occurring in the rest of the GIT, except rectal tumors, which are negative. In the liver, CK19 is of prognostic value in hepatocellular carcinomas and is of use in distinguishing cholangiocarcinoma from hepatocellular carcinomas.

Does CK19 stain mesothelial cells?

Conclusion: A panel of CEA, CK19 and HBME-1 monoclonal antibodies proved to be suitable for distinguishing carcinoma cells from reactive mesothelial cells in pleural effusions.

What does CK19 stain for?

CK19 has been shown to be an independent prognostic factor for pancreatic neuroendocrine tumors, especially the insulin-negative tumors. CK19 positive tumors are associated with poor outcome irrespective of the established pathologic parameters such as size, mitoses, lymphovascular invasion, and necrosis.

What does PAX8 positive mean?

PAX8-positive, calretinin-negative staining appears to be highly specific and sensitive for detecting metastatic ovarian serous carcinoma in cytological preparations and may prove useful for distinguishing these cells from mesothelial cells in fluid cytology (32).

What are calretinin neurons?

Calretinin is a member of the calcium-binding protein EF-hand family first identified in the retina. More recent experiments have revealed that calretinin plays a crucial role in the modulation of intrinsic neuronal excitability and the induction of long-term potentiation (LTP).

What is inhibin and calretinin?

Calretinin, a calcium-binding protein related structurally to S-100, and inhibin, a polypeptide hormone secreted primarily by ovarian granulosa cells and testicular Sertoli cells and functioning as an inhibitor for pituitary follicle-stimulating hormone secretion, are potentially useful but not well-evaluated markers …