What is Fragile X Syndrome article?
Fragile X syndrome (FXS) is the leading inherited form of intellectual disability and autism spectrum disorder, and patients can present with severe behavioural alterations, including hyperactivity, impulsivity and anxiety, in addition to poor language development and seizures.
What causes fragile X syndrome?
Fragile X syndrome (FXS) is a genetic disorder. FXS is caused by changes in a gene that scientists called FMR1 gene when it was first discovered. The FMR1 gene usually makes a protein called FMRP. FMRP is needed for brain development.
Is Fragile X Syndrome a neurodevelopmental disorder?
Fragile X syndrome is a monogenic neurodevelopmental disorder associated with intellectual disability and autism spectrum disorders.
What is fragile X syndrome also known as?
Fragile X syndrome (FXS), also known as Martin-Bell syndrome, is an inherited condition that causes developmental delays, intellectual disabilities, learning and behavioral issues, physical abnormalities, anxiety, attention-deficit/hyperactivity disorder and/or autism spectrum disorder, among other problems.
Does everyone have the FMR1 gene?
Everyone has the FMR1 gene on their X chromosome. 3. The FMR1 gene was identified in 1991. The “job” of the FMR1 gene is to make protein (FMRP) that is important in brain development.
Is a learning disability a neurodevelopmental disorder?
Examples of neurodevelopmental disorders in children include attention-deficit/hyperactivity disorder (ADHD), autism, learning disabilities, intellectual disability (also known as mental retardation), conduct disorders, cerebral palsy, and impairments in vision and hearing.
What are two of the most common neurodevelopmental disabilities?
Autism spectrum disorder (ASD) and attention deficit and hyperactivity disorder (ADHD) are the two most common neurodevelopmental disorders observed in childhood (1, 2).
What part of the brain is affected by learning disabilities?
The perisylvian region includes Wernicke’s area in the posterior left temporal lobe and Broca’s area in the premotor portion of the frontal lobe….PENNINGTON’S FIVE FUNCTIONAL DOMAINS.
| Domain | Location | Disorder |
|---|---|---|
| Long-term Memory | Hippocampus, Amygdala | Memory disorder / Amnesia |
What is the life expectancy of Fragile X syndrome?
Life expectancy for people with fragile X syndrome is generally normal. Many affected people participate in an active lifestyle and have good health.
What is the prognosis for Fragile X?
According to research, around 44% of women and 10% of men having fragile X syndrome are able to attain a high level of independence as adults. The life expectancy of a patient with fragile X syndrome is thought to be the same as any other normal person. The prognosis also depends on the degree of the symptoms of this condition.
Is fragile X syndrome the same as autism?
Fragile X syndrome is a leading genetic cause of autism. About one in three people with the syndrome also has autism. But even those who do not have autism often share certain autistic traits, such as avoidance of eye contact and difficulties in social situations.
What are the symptoms of Fragile X?
Fragile X Syndrome Symptoms. Though the severity of symptoms differs between men and women, some common fragile X syndrome symptoms are hyperactivity, impulsivity, anxiety, mood swings, tremors, and poor coordination.
