What is chloroquine used for?

Hydroxychloroquine and chloroquine are FDA-approved to treat or prevent malaria. Hydroxychloroquine is also FDA-approved to treat autoimmune conditions such as chronic discoid lupus erythematosus, systemic lupus erythematosus in adults, and rheumatoid arthritis.

How is chloroquine made?

Chloroquine, 7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline (37.1. 3), is made by reacting 4,7-dichloroquinoline (37.1. 1.1) with 4-diethylamino-1-methylbutylamine (37.1. 1.2) at 180 °C [1–3].

What is chloroquine Wikipedia?

Chloroquine is a medication primarily used to prevent and treat malaria in areas where malaria remains sensitive to its effects. Certain types of malaria, resistant strains, and complicated cases typically require different or additional medication.

What is the action of hydroxychloroquine?

Inhibition of lysosomal activity and autophagy An important mode of action of chloroquine and hydroxychloroquine is the interference of lysosomal activity and autophagy. It is widely accepted that chloroquine and hydroxychloroquine accumulate in lysosomes (lysosomotropism) and inhibit their function.

What is the brand name for chloroquine?

Chloroquine (also known as chloroquine phosphate) is an antimalarial medicine. It is available in the United States by prescription only. It is sold under the brand name Aralen, and it is also sold as a generic medicine.

What type of medication is hydroxychloroquine?

Hydroxychloroquine is in a class of drugs called antimalarials. It works by killing the organisms that cause malaria. Hydroxychloroquine may work to treat rheumatoid arthritis and systemic lupus erythematosus by decreasing the activity of the immune system.

Which tablet contains chloroquine?

ARALEN is an antimalarial and amebicidal drug. Each tablet contains 500 mg of chloroquine phosphate USP, equivalent to 300 mg chloroquine base.

How does chloroquine affect the immune system?

As will be discussed below, by accumulating in the acidic organelles, chloroquine exerts both direct antiviral effects on enveloped viruses and decreases activation of several cell types involved in the immune response.

Is chloroquine making a comeback?

Several years after it was banned as the first line drug for treatment of uncomplicated malaria, Chloroquine, one of the oldest anti-malaria drugs, appears to be gradually making a comeback. A decade and a half ago, Chloroquine was one of the most popular and efficacious anti-malaria drugs in the world.

Where is chloroquine still works?

There are only a few places left in the world where chloroquine is still effective including parts of Central America and the Caribbean. CDC keeps track of all the places in the world where malaria transmission occurs and which malaria drugs that are recommended for use in each place.

What is chloroquine made out of?

Chloroquine Phosphate is the phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. A.

What are the contra indications of chloroquine?

Chloroquine: Contraindications. Existing retinopathy. Epilepsy. Chloroquine: Cautions. Chloroquine can also be injected intramuscularly or intravenously; however, this is hardly ever necessary. Hydroxychloroquine has the same effects as chloroquine; amodiaquine, however, should not be used because of the dangers of agranulocytosis and hepatitis.