What is acinar cells of pancreas?

The pancreatic acinar cell is the functional unit of the exocrine pancreas. It synthesizes, stores, and secretes digestive enzymes. Under normal physiological conditions, digestive enzymes are activated only once they have reached the duodenum.

What is the structure of acinar cells?

Acinar cells are pyramidal, are oriented radially around a tiny, central lumen, and have intracytoplasmic, membrane-bound zymogen granules in the apical region. The more basophilic perinuclear region, containing the rough endoplasmic reticulum, gives the acinar cell a two-toned, apical–basal polarized appearance.

What is the histological structure of a pancreas?

The pancreas is divided into lobules by connective tissue septae. Lobules are composed largely of grape-like clusters of exocrine cells called acini, which secrete digestive enzymes.

What is the shape of pancreatic acinar cells?

Individual acinar cells have the shape of a truncated pyramid, arranged in groups around a central ductal lumen. These central ducts empty into progressively larger intercalated and collecting ducts that eventually join the pancreatic duct (duct of Wirsung).

What do the acinar cells of the pancreas secrete?

The exocrine cells (acinar cells) of the pancreas produce and transport chemicals that will exit the body through the digestive system. The chemicals that the exocrine cells produce are called enzymes. They are secreted in the duodenum where they assist in the digestion of food.

What do acinar cells secrete?

digestive enzymes
Ninety percent of the pancreas is composed of acinar cells which secrete digestive enzymes such as trypsin, chymotrypsin, and amylase for digestion of food in the small intestine. The acinar cells are triangular in shape and arranged in clusters with the apex of the cell opening into a centrally located terminal duct.

What do the pancreatic acinar cells secrete?

Pancreatic acinar cells secrete fluid and digestive enzymes.

What does the acinar cell secrete?

Pancreatic acinar cells synthesize and secrete almost all the digestive enzymes active in the lumen of the small intestine which are necessary for nutrient digestion. Both synthesis and secretion are highly regulated over both short and long time frames to insure an appropriate supply of digestive enzymes.

What does acinar mean?

An acinus (/ˈæsɪnəs/; plural, acini; adjective, acinar /ˈæsɪnər/ or acinous) refers to any cluster of cells that resembles a many-lobed “berry,” such as a raspberry (acinus is Latin for “berry”).

Where in the pancreas are acinar cells?

What are the secretions of pancreatic acinar cells?

Ninety percent of the pancreas is composed of acinar cells which secrete digestive enzymes such as trypsin, chymotrypsin, and amylase for digestion of food in the small intestine.

What is the role of acinar cells in the pancreas?

Pancreatic Acinar Cells. This H&E section of the exocrine pancreas shows several of its characteristic features. The exocrine cells show a strongly basophilic cytoplasm that represents the area occupied by the rough endoplasmic reticulum. The apical side of the cells is filled with zymogen granules that contain a variety of digestive enzymes.

Where are the secretory granules located in the pancreas?

Within the acinar cells you will see the basal rough endoplasmic reticulum and the numerous secretory granules in the apical region of the cells, facing the small lumen of the acinus. Note the centroacinar cell in upper right acinus.

Where does H & E stain in the pancreas?

Note that the peripheral region of each acinus, which represents the basal portions of the individual acinar cells, stains more blue or purple. The hematoxylin component of the H&E stain is staining the ribosomal RNA in the abundant rough (or granular) endoplasmic reticulum found in this portion of the secretory cells.

What kind of cytoplasm does acinar cell carcinoma have?

Cells show moderate amounts of granular eosinophilic cytoplasm containing PAS positive diastase resistant zymogen granules Can have different architectures and growth patterns, including cystic, acinar, glandular and intraductal