What is a lexiscan for the heart?
Lexiscan or Adenoscan are administered by intravenous injection during a cardiac nuclear stress test to patients who cannot adequately exercise. These drugs dilate the coronary arteries and increase blood flow so that coronary artery obstructions can be identified.
How does regadenoson work?
Regadenoson injection is used as a pharmacologic stress agent for radionuclide myocardial perfusion imaging (MPI) in patients unable to undergo adequate exercise stress. This medicine works by dilating the arteries of the heart and increase blood flow to help identify coronary artery disease.
Is regadenoson same as adenosine?
Regadenoson is a more potent vasodilator than adenosine and exhibits selectivity for the coronary circulation relative to the renal, peripheral and mesenteric circulation in animals [5]. Adenosine is nonselective and causes negative chronotropic, dromotropic and inotropic effects via A1 receptors.
What is the half life of lexiscan?
The maximal plasma concentration of regadenoson is achieved within 1 to 4 minutes after injection of LEXISCAN and parallels the onset of the pharmacodynamic response. The half-life of this initial phase is approximately 2 to 4 minutes.
What is regadenoson myocardial perfusion?
Novel pharmacologic stressor regadenoson is A2A selective adenosine agonist, which selectively binds to the adenosine receptors in coronary arteries causing coronary dilatation.
Is regadenoson a generic?
The generic ingredient in LEXISCAN is regadenoson. There are nine drug master file entries for this compound.
What is the difference between adenosine and Lexiscan?
What is an Adenosine or Lexiscan nuclear scan? It is similar to the exercise nuclear stress test except for the fact that Adenosine or Lexiscan is used to stress the heart. Adenosine is infused over 4-6 minutes, while Lexiscan is given over a few seconds.
What is another name for Lexiscan?
One is Lexiscan (the brand name for regadenoson). This drug is given to simulate or augment the effects of stress by dilating blood vessels in the heart and allowing changes in blood flow to the heart to be assessed by pictures taken using the radiopharmaceutical.
When does Lexiscan go generic?
Lexiscan was eligible for patent challenges on April 10, 2012. By analyzing the patents and regulatory protections it appears that the earliest date for generic entry will be February 2, 2027. This may change due to patent challenges or generic licensing.
Can Lexiscan cause a stroke?
Lexiscan can cause stroke, which may be a result of an increase or decrease in blood pressure.
What does cardiac output mean in medical terms?
Introduction Cardiac output (CO) is the amount of blood pumped by the heart minute and is the mechanism whereby blood flows around the body, especially providing blood flow to the brain and other vital organs.
How is cardiac output estimated from a catheter?
The PiCCO system continually estimates the stroke volume from the arterial waveform, using an arterial catheter. Cardiac output is then estimated from the stroke volume and heart rate. Provides continuous beat by beat parameters which are obtained from the shape of the arterial pressure wave
How is the output of the heart affected?
The body’s demand for oxygen changes, such as during exercise, and the cardiac output is altered by modulating both heart rate (HR) and stroke volume (SV). As a result, the regulation of cardiac output is subject to a complex mechanism involving the autonomic nervous system, endocrine, and paracrine signaling pathways.[1]
How to diagnose patients with decreased cardiac output?
Patient demonstrates adequate cardiac output as evidenced by blood pressure and pulse rate and rhythm within normal parameters for patient; strong peripheral pulses; and an ability to tolerate activity without symptoms of dyspnea, syncope, or chest pain. Patient exhibits warm, dry skin, eupnea with absence of pulmonary crackles.
