What is a good HLA match for kidney transplant?

The best match for the recipient is to have 12 out of s12antigen match. (This is known as a zero mismatch.) It is possible for all 12 markers to match, even with an unrelated deceased donor organ, if the patient has a very common HLA type.

Is HLA important for kidney transplant?

Following the first successful kidney transplant between identical twin siblings in 1954, the importance of matching for human leukocyte antigens (HLA) in kidney transplantation was demonstrated in studies that showed better graft survival in HLA identical kidney transplants compared with HLA mismatched transplants [1] …

What is HLA in kidney transplant?

When the immune system of the recipient recognizes the transplanted kidney as a foreign object, graft rejection occurs. As part of the host immune defense mechanism, human leukocyte antigen (HLA) is a major challenge for graft rejection in transplantation therapy.

What tests are needed to donate a kidney?

There are three main blood tests to check for compatibility between donor and recipient:

• Blood type test. This makes sure your blood type and the recipient’s blood type are a good match.
• Crossmatch test. Doctors mix a sample of your blood with a sample of the recipient’s to see how they react.
• HLA typing.

How common is an HLA match?

Sometimes, it’s hard to find a match because some HLA types are less common. HLA types are inherited so siblings can sometimes be a match for each other. Each of your brothers and sisters who has the same mom and dad as you has a 1 in 4 chance (25%) of being a complete, or full, match.

What is a perfect kidney match?

To receive a kidney where recipient’s markers and the donor’s markers all are the same is a “perfect match” kidney. Perfect match transplants have the best chance of working for many years. Most perfect match kidney transplants come from siblings.

How much does HLA testing cost?

On MDsave, the cost of an HLA Typing, Single Antigen ranges from $39 to $78. Those on high deductible health plans or without insurance can save when they buy their procedure upfront through MDsave.

Why is HLA-DR more important?

Antigens most responsible for graft loss are HLA-DR (first six months), HLA-B (first two years), and HLA-A (long-term survival). Good matching of these antigens between host and donor is most critical for achieving graft survival.

Can you donate organs if you have HLA antibodies?

You do not need to do anything if you test positive for HLA antibodies. Your HLA antibodies pose absolutely no risk to you. You will remain eligible to donate red blood cells. Unfortunately, you will no longer be eligible to donate plasma or plasma blood products, such as platelets collected by apheresis.

What would disqualify you from donating a kidney?

As a general rule, you should be 18 years or older . You must also have normal kidney function . There are some medical conditions that could prevent you from being a living donor . These include having uncontrolled high blood pressure, diabetes, cancer, HIV, hepatitis, or acute infections .

Does it shorten your life to donate a kidney?

No Life Expectancy Changes Donating a kidney does not affect a person’s life expectancy. On the contrary, studies show that people who donate a kidney outlive the average population. Twenty years after donating, 85 percent of kidney donors were still alive, while the expected survival rate was 66 percent.

How long does it take to get HLA results?

Results of your HLA typing After MSK gets your HLA test sample, it usually takes about 1 to 2 weeks for your results to come back. If your results show your pattern of HLA markers is like the patient’s, it means you’re a potential donor.

How are blood tests done for kidney donation?

You may have heard discussions about “matching” and kidney transplantation. There are actually three tests that are done to evaluate donors. They are blood type, crossmatch, and HLA testing. This blood test is the first step in the process of living donation and determines if you are compatible or a “match” to your recipient.

What does HLA stand for in organ transplant?

HLA typing is also called “tissue typing”. HLA stands for human leukocyte antigen. Antigens are proteins on the cells in the body. Out of over 100 different antigens that have been identified, there are six that have been shown to be the most important in organ transplantation.

What happens if you test positive for HLA antibodies?

If you test positive for HLA antibodies, you are considered “sensitized” and your PRA percentage will be greater than 0. The more HLA antibodies that you have in your blood, the higher the PRA percentage. It is important to test for the presence of these HLA antibodies before your transplant.

How can you tell if you are a compatible kidney donor?

There are actually three tests that are done to evaluate donors. They are blood type, crossmatch, and HLA testing. This blood test is the first step in the process of living donation and determines if you are compatible or a “match” to your recipient.