What happens when TSH receptors are stimulated?
Over-activation of the cAMP pathway by chronic TSHR stimulation causes excess hormone secretion and thyroid hyperplasia, which results in clinical hyperthyroidism. Increased secretion of the thyroid hormone than leads to negative feedback at the hypothalamic-pituitary level resulting in suppressed TSH secretion.
What is the function of thyroid stimulating hormone receptor?
The thyroid-stimulating hormone (TSH, or thyrotropin) receptor (TSHR) mediates the activating action of TSH to the thyroid gland, resulting in the growth and proliferation of thyrocytes and thyroid hormone production.
What stimulates thyroid stimulating?
The hypothalamus and the pituitary gland, which are located in the brain, help control the thyroid gland. The hypothalamus releases thyrotropin-releasing hormone (TRH), which stimulates the pituitary gland to release thyroid-stimulating hormone (TSH).
Does dopamine activate TSH release?
Dopamine also inhibits basal and TRH-stimulated TSH secretion in vivo and in vitro at concentrations that exist in the pituitary portal blood [189]. This leads to inhibition of adenylate cyclase, which decreases the synthesis and secretion of TSH.
What happens if thyroid stimulating hormone is low?
Symptoms of low TSH include weight loss, fatigue, confusion, heat intolerance, fast heartbeat, high blood pressure and other symptoms. The endocrine system is responsible for regulating the function of organs in your body.
How do you control thyroid stimulating hormone?
Treatment
- Radioactive iodine to slow down your thyroid.
- Anti-thyroid medications to prevent it from overproducing hormones.
- Beta blockers to reduce a rapid heart rate caused by high thyroid levels.
- Surgery to remove the thyroid (this is less common)
What inhibits TSH release?
Somatostatin, on the other hand, is another hormone produced by the hypothalamus that inhibits the release of TSH from the anterior pituitary.
How is TSH inhibited?
Secretion of thyroid-releasing hormone, and hence, TSH, is inhibited by high blood levels of thyroid hormones in a classical negative feedback loop.
