What happens if you overdose on clomipramine?
An overdose of clomipramine can be fatal. Overdose symptoms may include irregular heartbeats, feeling restless or agitated, confusion, severe sweating, slow or jerky muscle movements, extreme drowsiness, slow breathing, feeling like you might pass out, seizure, or coma.
How much clomipramine is too much?
The initial recommended dose of clomipramine is 25 mg daily. The dose should be gradually increased, as tolerated, to approximately 100 mg daily during the first 2 weeks. The maximum recommended dose of clomipramine is 250 mg daily.
Can clomipramine cause seizures in dogs?
Signs of Toxicity/Overdose Overdose of Clomipramine could be life threatening and cause such things as: Seizures. Abnormal Heart Rhythm.
What are the side effects of clomipramine in dogs?
Common side effects include lack of appetite, vomiting, diarrhea, constipation, dry mouth, elevated liver enzymes, difficulty urinating, or tiredness.
What is clomipramine used for in dogs?
“Clomipramine was the first licensed medication for the treatment of any behavioral condition in dogs, and has been a boon for dogs affected with separation anxiety,” Overall said. The medication is also used extralabel to treat obsessive-compulsive disorder (OCD) and other anxiety-related conditions in dogs and cats.
What is the half life of clomipramine?
The apparent elimination half-life of clomipramine is about 24h and that of demethyl-clomipramine, 96h. Accordingly, the time to reach steady-state for both active moieties is in general around 3 weeks.
How long until clomipramine is out of your system?
Clinical evidence indicates that after a 150 mg dose, the half-life of clomipramine is 32 hours. Clomipramine’s active metabolite has a mean half-life of 69 hours. Elimination half-lives can be considerably lengthened when doses exceed 150 mg.
What does Prozac do for dogs?
Fluoxetine (brand names: Prozac®, Reconcile®, Sarafem®) is an SSRI antidepressant used to treat a variety of behavioral disorders in dogs and cats. The FDA approved form for dogs is labeled to treat separation anxiety.
How long does it take for clomipramine to work in dogs?
Do not give this medication without first consulting with your veterinarian if your pet has worn a flea or tick collar in the past two weeks. This medication can take a few weeks before full effects are noted, but side effects can occur immediately. Gradual improvements are usually noticeable after a few days.
Is fluoxetine safe for dogs?
Dogs and Cats Fluoxetine is FDA-approved for use in separation anxiety in dogs. All other uses of fluoxetine in dogs and cats are extra-label but there is considerable literature and experience on the use of SSRI’s for small-animal behavior problems.
How long does it take for clomipramine to work on dogs?
ClomiCalm should be used as part of a comprehensive behavioral management program to treat separation anxiety in dogs greater than six months of age. It may take up to 8 weeks to determine if the ClomiCalm is working.
Do you have to wean your dog off ClomiCalm?
Clomipramine is a tricyclic antidepressant that works by increasing levels of serotonin in the brain to balance out mood. As with any antidepressant, it is important to wean your dog on to a full dose, beginning with the smallest dose possible and increasing that dose over long intervals.
