What does transferrin receptor bind?

Tf is a bi- lobal protein that binds one ferric ion per lobe with exceptionally high affinity 1, and serves to solubilize the ferric ion for transport in blood. Circulating, holo-Tf binds to the cell-surface transferrin receptor-1 (TfR1) and is endocytosed.

What does TFR2 gene do?

The TFR2 gene provides instructions for making a protein called transferrin receptor 2. The main function of this protein is to help iron enter liver cells (hepatocytes).

How does iron regulate transferrin receptor gene expression?

For most non-erythroid cells, iron can regulate the TfR expression in a reciprocal manner through modulating the stability of the receptor mRNA whereas in hemoglobin-synthesizing cells, the TfR expression is independent of the cellular iron loading.

What is soluble transferrin receptor test?

Soluble transferrin receptors are proteins found in blood that can be elevated with iron deficiency. This test measures the amount of soluble transferrin receptors to help detect and evaluate iron deficiency and aid in the diagnosis of iron deficiency anemia. Iron is an essential nutrient absorbed from the diet.

What cells express transferrin receptor?

Transferrin receptor (TfR) is a transmembrane glycoprotein which is widely expressed in various sites of human body with different levels. For example, TfR is highly expressed by red blood cells, brain endothelial cells, and several types of tumor cells. In comparison, TfR expression by the other kinds of cells is low.

What is hereditary hemochromatosis?

Hereditary hemochromatosis is a genetic disorder that can cause severe liver disease and other health problems. Early diagnosis and treatment is critical to prevent complications from the disorder. If you have a family health history of hemochromatosis, talk to your doctor about testing for hereditary hemochromatosis.

Is transferrin the same as ferritin?

Ferritin is stored in the body’s cells until it’s time to make more red blood cells. The body will signal the cells to release ferritin. The ferritin then binds to another substance called transferrin. Transferrin is a protein that combines with ferritin to transport it to where new red blood cells are made.

What happens if your transferrin saturation is low?

A low transferrin saturation usually indicates iron deficiency while a high saturation often confirms haemochromatosis.