What does the extracellular matrix of bone consist of?

Extracellular matrix, which is made up of an organic matrix (30%) containing proteoglycans (but less than cartilage), glycosaminoglycans, glycoproteins, osteonectin (anchors bone mineral to collagen) and osteocalcin (calcium binding protein). There are collagen fibres (mostly type I (90%), with some type V).

What are three important components of the extracellular matrix of bone?

In biology, the extracellular matrix (ECM) is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.

What are the two main components of the extracellular matrix of bone quizlet?

What are the two major components of bone matrix? Calcium salts that compose 2/3 of a Bone’s weight; includes calcium phosphate and calcium carbonate; the two combine to create crystals of hydroxyapatite on the collagen fibers. Calcium salts are strong and CAN handle compression but NOT twisting forces.

What is the matrix for bone cells?

The organic matrix of bone is composed of collagen and non-collagenous organic materials. Collagen comprises about 90% of the organic bone matrix. Type I collagen is the most abundant form of intrinsic collagen found in the bone that is secreted by osteoblasts.

What is extracellular matrix in cartilage?

Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS).

What is the extracellular matrix of tendons and ligaments?

The extracellular matrix of tendons is largely composed of collagen fiber network and less proteoglycans, elastin, and other proteins. The main task of these components is to maintain the structure of the tendon and facilitate the biomechanical reaction of the tissue against mechanical loads.

What type of fibers or minerals are in the extracellular matrix of bone?

One type of fiber found in the extracellular matrix of the bone is collagen. This type of fiber is extremely strong and makes of 90% of the bone (this is the most abundant protein in the body, not all in the matrix). Another important aspect is the different minerals of calcium salts.

What are two main components of the extracellular matrix of bone?

Two main classes of extracellular macromolecules make up the matrix: (1) polysaccharide chains of the class called glycosaminoglycans (GAGs), which are usually found covalently linked to protein in the form of proteoglycans, and (2) fibrous proteins, including collagen, elastin, fibronectin, and laminin, which have …

What are the components of the extracellular matrix quizlet?

Extracellular Matrix

• collagen fibers.
• elastin fibers.
• proteoglycans.
• glycosaminoglycans.
• large adhesive glycoproteins.

Which components are part of the bone matrix?

The organic component of the bone matrix includes the collagen and ground substance whereas the inorganic component is the inorganic bone salts, mainly the hydroxyapatite. The collagen and ground substance form approximately 25% of the bone mass. Collagen, though, is the predominant organic component.

What protein are bone matrix fibers are composed of?

collagen
collagen is the major structural component of the bone matrix, whereby the majority is type I collagen (∼90%) with smaller amounts of collagen types III, V, X and XII. collagen is a fibrous protein that has a rope-like structure made up of ∼1000 amino acids and is ∼300 nm in length.

What makes up the extracellular matrix of bone?

Extracellular matrix, which is made up of an organic matrix (30%) containing proteoglycans (but less than cartilage), glycosaminoglycans, glycoproteins, osteonectin (anchors bone mineral to collagen) and osteocalcin (calcium binding protein). There are collagen fibres (mostly type I (90%), with some type V). Click to see full answer.

What are the macromolecules in the extracellular matrix?

Extracellular matrix. In biology, the extracellular matrix ( ECM) is a three-dimensional network consisting of extracellular macromolecules and minerals, such as collagen, enzymes, glycoproteins and hydroxyapatite that provide structural and biochemical support to surrounding cells.

How is collagen a component of the extracellular matrix?

Their sturdiness lends the extracellular matrix its buffering and force-resisting properties that can withstand environmental pressures without collapsing. Collagen is actually a main structural component of not only the matrix, but also of multicellular animals.

How is scaffolding used to describe the extracellular matrix?

Scaffolding, in turn, is a term used to describe the ephemeral structures that form between individual proteins to make more elaborate protein polymers. These rigid, albeit temporary protein structures will lend the matrix a viscous consistency.