What does Coronin protein do?
Coronin is a conserved actin binding protein that promotes cellular processes that rely on rapid remodeling of the actin cytoskeleton, including endocytosis and cell motility.
What type of protein is Coronin?
actin binding protein
Coronin is an actin binding protein which also interacts with microtubules and in some cell types is associated with phagocytosis. Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to humans.
Where is Coronin found in the human body?
Coronin was first identified in Dictyostelium and was characterized as an actin-binding protein. Consistent with the previous reports22,24,30, coronin 1A was distributed near the plasma membrane and co-localized to F-actin (Fig. 1c). Of note, coronin 1A was detected in osteoclast precursor cells (Fig.
Why is Coronin important?
Recently, it has been demonstrated that coronin 1 is necessary to activate calcium signalling after the entry of mycobacteria into the macrophages, because absorption of these bacteria is associated with a transient increase in intracellular calcium ion concentration [30, 44–48].
Where is Coronin protein found?
Coronin is a widely studied actin-binding protein. It accumulates at actin-rich structures like macropinosomes, phagosomes, and the leading pseudopod of aggregating cells and its roles in cytokinesis, endocytosis, and cell motility are well established (Rivero, 2008; Rivero and Eichinger, 2005; Shina and Noegel, 2008).
What does actin attach to?
myosin filaments
The actin filaments are attached at their plus ends to the Z disc, which includes the crosslinking protein α-actinin. The myosin filaments are anchored at the M line in the middle of the sarcomere.
What is actin made from?
Actin filaments are made up of identical actin proteins arranged in a long spiral chain. Like microtubules, actin filaments have plus and minus ends, with more ATP-powered growth occurring at a filament’s plus end (Figure 2). Figure 3: Actin filaments support a variety of structures in a cell.
Where are coronin proteins found in the body?
Coronin proteins are expressed in a large number of eukaryotic organisms from yeast to humans. Initially, a 55 kDa protein was isolated from the actomyosin complex of Dictyostelium discoideum, which was later shown to bind actin in vitro.
Why is coronin 1B needed for cell protrusion?
Coronin 1B is required for efficient cell protrusion and migration. Recent study demonstrates that coronin 1B inhibits the Arp2/3 complex activity by replacing it at the branched actin structure.
What kind of structure does coronin 1A have?
Coronin belongs to the WD-repeat containing proteins, which form a beta propeller tertiary structure. The crystal structure of coronin 1A (see figure to the right) containing major part of the protein was solved in 2006.
What is the function of the CORO1A gene?
Coronin-1A is a protein that in humans is encoded by the CORO1A gene. It has been implicated in both T-cell mediated immunity and mitochondrial apoptosis. In a recent genome-wide longevity study, its expression levels were found to be negatively associated both with age at the time of blood sample and the survival time after blood draw.
