What does an elevated SDMA mean?

An elevated SDMA concentration is a reflection of impaired glomerular filtration rate (GFR). Both primary kidney disease. and secondary kidney insults, such as concurrent disease, can cause an elevation in SDMA concentration.

What is SDMA kidney?

Symmetric dimethylarginine (SDMA) is a sensitive circulating kidney biomarker whose concentrations increase earlier than creatinine as glomerular filtration rate decreases. Unlike creatinine SDMA is unaffected by lean body mass.

Can SDMA be falsely elevated?

SDMA correlates with strongly with GFR. There are no known interferences that are expected to cause a falsely increased SDMA. SDMA increases only when GFR is reduced. However, if GFR is reduced with prerenal or postrenal azotemia, then SDMA will increase accordingly.

Is SDMA affected by dehydration?

Does dehydration impact IDEXX SDMA concentration? If dehydration results in a prerenal azotemia reflecting a reduction in GFR, then SDMA should also increase.

How accurate is SDMA?

A published study in cats found the sensitivity of SDMA to be 100% and the specificity to be 91% when compared to the gold standard of GFR.

When should I run SDMA?

Run SDMA every time you run creatinine and BUN SDMA is more reliable than creatinine as an indicator of kidney function because it is not influenced by confounding conditions. SDMA is an earlier indicator of progressive kidney function loss, often increasing before other parameters.

Is SDMA affected by UTI?

Discussion. SDMA is a more sensitive indicator of kidney function than creatinine in AKI as well as CKD and increases earlier. In pets like Reese, an increased SDMA in the face of a urinary tract infection should lead to additional investigation and a consideration for more aggressive treatment for pyelonephritis.

Can SDMA go down?

Hemolysis, if present, can result in decreased SDMA. SDMA and creatinine can both be affected by biologic and assay variability resulting in fluctuations around the upper end of the reference interval; this can be seen with well-managed stable CKD and results will likely align as disease progresses.

What would increase glomerular filtration rate?

Here are some tips to increase your glomerular filtration rate: Try drinking isotonic fluid. Drinking such fluids causes your blood volume to increase and thus your blood pressure as well. Make sure you avoid taking anti-cholinergic drugs. Such drugs cause water retention in your bladder. Make sure you drink plenty of water.

What is the treatment for decreased kidney function?

If the kidneys cannot keep up with waste and fluid clearance on their own, you most definitely will require dialysis or a kidney transplant. Dialysis gets rid of the waste products and surplus fluids from the bloodstream when the kidneys can no longer do it.

How can i Improve my renal function?

A popular home remedy to improve renal function is drinking a glass or two of cranberry juice each day, while avoiding excessive amounts of caffeine and alcohol. Cranberry juice helps to cleanse the kidneys, bladder, and urinary tract by flushing out harmful bacteria.

What are the symptoms of reduced renal function?

Treatment For Decreased Kidney Function: Causes And Symptoms Causes Of Decreased Kidney Function. Glomerulonephritis – inflammation of the glomeruli. Signs And Symptoms Of Decreased Kidney Function. Changes in how much you urinate. Treatment Options For Decreased Kidney Function. Treatment comprises of ways to control signs and symptoms, lessen complications, and decelerate progression of the disease.