What does a Cryoglobulin test show?

A cryoglobulins test is used to help detect the presence and relative quantity of cryoglobulins in the blood. It may be ordered along with other tests to help determine or rule out potential causes of cryoglobulinemia. The tests ordered depend on what condition or disease is suspected.

What is cryoglobulinemia mean?

Cryoglobulinemia is the presence of abnormal proteins in the blood. These proteins thicken in cold temperatures.

Which antibodies are found in cryoglobulinemia?

Cryoglobulins. Cryoglobulins consists of one or more of the following components: monoclonal or polyclonal IgM, IgG, IgA antibodies, monoclonal κ, or λ free light chain portions of these antibodies, and proteins of the blood complement system, particularly complement component 4 (C4).

How do you diagnose cryoglobulinemia?

Diagnosis of cryoglobulinemia involves a blood test in which the sample must be kept at normal body temperature, 98.6 F (37 C), for a period of time before being cooled. Inaccurate test results can occur if the blood sample isn’t handled properly.

What does a positive Cryoglobulin mean?

If you test positive for cryoglobulins, it means these proteins became visibly thickened when your blood sample was chilled. Your healthcare provider will do more tests to find out the cause.

How do you treat Cryoglobulins?

Cryoglobulinemia is commonly treated with corticosteroids such as prednisone, and medications that suppress the immune system. Antiviral drugs are prescribed when HCV is present. Left untreated, the disease can cause permanent tissue and organ damage, so it is important to seek prompt medical care when symptoms appear.

How many people have cryoglobulinemia?

Cryoglobulinemia is considered a rare disease. Cryoglobulins are reported in otherwise healthy people, so the actual prevalence of the disease is not known. Prevalence is estimated at approximately 1 per 100,000 worldwide.