What are the side effects of platinum complex?
Other common side effects include anaphylaxis, cytopenias (including leukopenia and neutropenia, thrombocytopenia, and anaemia), hepatotoxicity, ototoxicity, cardiotoxicity, nausea and vomiting, diarrhea, mucositis, stomatitis, pain, alopecia, anorexia, cachexia, and asthenia.
What cancers does platinum treat?
Cisplatin, the most common platinum chemotherapy drug, was first approved in the US in 1978. It is particularly effective against testicular cancer, and is also used in the treatment of ovarian and some lung cancers, as well as lymphoma and other cancers.
What are platinum IV drugs?
Pt(iv) prodrugs represent a promising class of “non-conventional” platinum-based anticancer agents to circumvent drug resistance, which can be easily functionalized with other bioactive ligands.
Is platinum is used as an anticancer drug?
Cisplatin, carboplatin and oxaliplatin are platinum-based drugs that are widely used in cancer chemotherapy. Platinum–DNA adducts, which are formed following uptake of the drug into the nucleus of cells, activate several cellular processes that mediate the cytotoxicity of these platinum drugs.
What do platinum drugs do?
Doctors use platinum drugs to treat many kinds of cancer, both alone and in combination with other drugs. Cisplatin, the oldest, has been approved as a cancer treatment since 1978. In the U.S., two other platinum-containing molecules are also approved cancer drugs: carboplatin and oxaliplatin.
Which chemo drugs contain platinum?
Platinum-based anticancer drugs, including cisplatin, carboplatin, oxaliplatin, nedaplatin, and lobaplatin, are heavily applied in chemotherapy regimens. However, the intrinsic or acquired resistance severely limit the clinical application of platinum-based treatment.
How does platinum chemo work?
Platinum-Based Drugs (Cisplatin, Carboplatin) These drugs form highly reactive platinum complexes that bind and crosslink DNA, a double-stranded molecule inside the nucleus of the cell that controls cellular activity. The chemical crosslinking within the DNA prevents cancer cells from growing and causes them to die.
What is the difference between platinum II and platinum IV?
Compared to the commonly used Pt(II) compounds cisplatin and oxaliplatin, the recently reported complexes containing Pt(IV) seem to have several advantages; they are safer, can be used orally, have a higher scope of anticancer effect, and do not show cross-resistance to cisplatin.
How do platinum drugs work?
What is platinum chemo?
Platinum-based antineoplastic drugs (informally called platins) are chemotherapeutic agents used to treat cancer. They are coordination complexes of platinum. These drugs are used to treat almost half of people receiving chemotherapy for cancer.
What are the effects of platinum?
What are the different types of platinum based drugs?
Here, we review the main classes of new platinum drug candidates, such as sterically hindered complexes, monofunctional platinum drugs, complexes with biologically active ligands, trans-configured and polynuclear platinum complexes, platinum(IV) prodrugs and platinum-based drug delivery systems.
Are there any side effects to platinum based chemotherapy?
In total, a cancer patient can experience a … The side effects of platinum-based chemotherapy drugs: a review for chemists Dalton Trans. 2018 May 15;47(19):6645-6653.doi: 10.1039/c8dt00838h. Authors
Are there any new platinum-based anticancer drugs?
Much effort has been put into the development of new platinum anticancer complexes, but none of them has reached worldwide clinical application so far. Nedaplatin, lobaplatin and heptaplatin received only regional approval. Some new platinum complexes and platinum drug formulations are undergoing clinical trials.
