What are Mikulicz cells?
Medical Definition of Mikulicz cell : a round or oval macrophage with a small nucleus that is found in the nodules of rhinoscleroma and contains the causative bacterium (Klebsiella rhinoscleromatis)
How is Rhinoscleroma diagnosed?
This chronic infectious disease of the upper respiratory tract is routinely diagnosed by means of tissue biopsy of the lesions. Nasal endoscopy reveals signs of all 3 stages of scleroma: catarrhal, granulomatous, and sclerotic. Bronchoscopy has a role in the early diagnosis of rhinoscleroma.
What causes Rhinoscleroma?
Rhinoscleroma is caused by the gram-negative coccobacillus K rhinoscleromatis. Although crowded conditions, poor hygiene, and poor nutrition appear to be necessary for transmission of the infectious agent, the actual pathogenesis of infection remains elusive.
Where is Klebsiella aerogenes found?
K. aerogenes is generally found in the human gastrointestinal tract and does not generally cause disease in healthy individuals. It has been found to live in various wastes, hygienic chemicals, and soil.
Who described Rhinoscleroma?
It was first described by Ferdinando Von Hebra in 1870 (3). Rhinoscleroma is an infectious disease caused by the bacterium Klebsiella rhinoscleromati, an encapsulated gram-negative member of Enterobacteriaceae that can be isolated by culture medium.
What causes Klebsiella aerogenes?
aerogenes result from specific antibiotic treatments, venous catheter insertions, and/or surgical procedures. K. aerogenes is generally found in the human gastrointestinal tract and does not generally cause disease in healthy individuals. It has been found to live in various wastes, hygienic chemicals, and soil.
Is Klebsiella aerogenes a STD?
Granuloma inguinale is caused by a gram-negative bacterium by the name of Klebsiella granulomatis. This is an extremely rare STD, with about 100 cases occurring annually in the United States.
Is there a cure for atrophic rhinitis?
The first-line treatment for AR includes nasal irrigation. This treatment can help reduce crusting in the nose by improving tissue hydration. You must irrigate your nose several times a day. The irrigation solution may consist of saline, a mixture of other salts, or even an antibiotic solution.
Where are Mikulicz cells found in the body?
Characteristic Mikulicz cells (foamy histiocytes) and plasma cells were seen in the sub epithelium (Fig. 20) The disease is due to an altered immune response with impaired cellular immunity, leading to accumulation of distended phagosomes, called Mikulicz cells.
Where are the glands located in Mikulicz syndrome?
Mikulicz syndrome is a chronic condition characterized by the abnormal enlargement of glands in the head and neck, including those near the ears (parotids) and those around the eyes (lacrimal) and mouth (salivary).
Who was Jan Mikulicz-Radecki and what did he do?
Jan Mikulicz-Radecki (1850-1905) was the cofounder of modern surgery, aseptic techniques, and the inventor of gastroscopy, but his professional accomplishments go far beyond the field of surgical treatment.
Can a person with Mikulicz syndrome get lymphoma?
People who have Mikulicz syndrome are at heightened risk for developing lymphomas. Some people with Mikulicz syndrome may experience recurring fevers. The fever may be accompanied by dry eyes, diminished tear production (lacrimation), and inflammation of various parts of the eyes (uveitis).
