Is etomidate contraindicated in sepsis?
The most rigorous meta-analysis suggests that etomidate can be safely used in septic patients (19).
When should etomidate not be used?
Etomidate: Unsafe for Intubation in Patients with Sepsis? Etomidate is commonly used for rapid sequence intubation; however, even after one dose, it has been associated with adrenal axis suppression in critically ill patients.
Why is etomidate used in RSI?
Etomidate is a carboxylated imidazole compound that was introduced in Europe in 1972. It is used increasingly for RSI of ED patients because of its rapid onset of anaesthesia, haemodynamic stability, cerebral protective properties, and lack of respiratory depression.
Why use etomidate?
Etomidate is commonly used for the facilitation of endotracheal intubation. While etomidate possesses multiple qualities that are beneficial in hemodynamically unstable patients who require a sedative or amnestic, its potential to negatively impact corticosteroid production is well-documented.
Why is etomidate avoided in septic shock?
The agent is therefore attractive for use in critically ill patients who have a high risk of hemodynamic instability during this procedure. However, etomidate causes adrenal suppression, which itself has been associated with increased mortality in critically ill patients.
What receptors does etomidate work?
Etomidate acts on the CNS to stimulate gamma-aminobutyric acid (GABA) receptors and, in doing so, depresses the reticular activating system. The electroencephalogram (EEG) changes are similar to those produced by barbiturates as the patient passes rapidly through light to deep levels of surgical anesthesia.
How is etomidate administered?
It is administered only by intravenous route. Etomidate has a very favorable hemodynamic profile on induction, with a minimal amount of blood pressure depression, making it an ideal choice for shock trauma, hypovolemic patients, or patients with significant cardiovascular disease.
What is the action of etomidate?
