Is eprinomectin the same as ivermectin?

Although topical preparations of both eprinomectin and ivermectin have high efficacy against S. scabiei, eprinomectin has an edge over ivermectin, owing to its zero milk and meat withdrawal time (Alvinerie et al. 1999), and the efficacy is not affected by coat length, rain and weather (Gogolewski et al.

How does eprinomectin work?

Eprinomectin binds to glutamate gated chloride channels that are present in invertebrate nerve and muscle cells and increases the permeability of the cell membrane to chloride ions that triggers hyperpolarization of the nerve or muscle cell resulting in paralysis and death of the parasite.

Can you use eprinex on cats?

While the use of eprinomectin has been characterized in several species other than cattle, it is a new anthelmintic compound for cats. In both laboratory and field studies, it has been shown to be well tolerated in adult cats and kittens.

Is Centragard safe for cats?

CENTRAGARD ™ (eprinomectin and praziquantel transdermal solution), innovative internal parasite protection for cats, launched in the U.S. Heartworm disease is a serious and potentially deadly threat to cats.

Is Eprinomectin safe for dogs?

In a 14-week repeated toxicity study carried out in dogs, eprinomectin was administered at level doses of 0, 0.4, 0.8 and 1.6 mg/kg bw/day. Animals treated with the highest dose showed mydriasis, ataxia, salivation. A NOEL of 0.8 mg/kg bw/day was retained for this study.

What happens if cat licks Centragard?

ADVERSE REACTIONS When cats licked the application site after treatment, temporary excessive salivation was observed. Oral ingestion of CENTRAGARD may also result in hypersalivation, vomiting and/or lethargy.

How do you give a cat Centragard?

To apply Centragard to your cat, pull back the plunger of the applicator slightly and remove the cap. Part your cat’s hair in one spot on the midline of the neck between the base of the skull and the shoulder blades, place the top of the applicator on the skin and empty the entire contents directly onto the skin.

What is Selamectin for cats?

Selamectin is a broad-spectrum avermectin endectocide that is safe for use in cats starting at six weeks of age, including heartworm-infected cats and cats of reproducing age, when administered topically to the skin monthly at the recommended dosage to deliver at least 6mgkg(-1).

Can you use ivermectin pour on on cats?

Recommended and Extra-Label Use Ivermectin is approved by the FDA for use as a heartworm preventative in cats. The recommended minimum dose in cats is 24 µg/kg of body weight.

How does milbemycin oxime work?

Milbemycin oxime is produced by Streptomyces hygroscopicus aureolacrimosus. It opens glutamate sensitive chloride channels in neurons and myocytes of invertebrates, leading to hyperpolarisation of these cells and blocking of signal transfer.