How many mg of lorazepam should I take a day?

To facilitate this, 0.5 mg, 1 mg, and 2 mg tablets are available. The usual range is 2 to 6 mg/day given in divided doses, the largest dose being taken before bedtime, but the daily dosage may vary from 1 to 10 mg/day.

What is the half life of 2 mg of lorazepam?

The peak plasma level of lorazepam from a 2 mg dose is approximately 20 ng/mL. The mean half-life of unconjugated lorazepam in human plasma is about 12 hours and for its major metabolite, lorazepam glucuronide, about 18 hours. At clinically relevant concentrations, lorazepam is approximately 85% bound to plasma proteins.

Are there any side effects to taking lorazepam?

As with all benzodiazepines, the use of lorazepam may worsen hepatic encephalopathy; therefore, lorazepam should be used with caution in patients with severe hepatic insufficiency and/or encephalopathy.

When to increase lorazepam dosage for renal failure?

-For debilitated patients, an initial dosage of 1 to 2 mg/day in divided doses is recommended. -The dosage should be increased gradually when needed to help avoid adverse effects. -Renal failure: Not recommended. -Infrequent doses and/or doses given over a long period of time: No adjustment recommended. Liver failure: Not recommended.

When to reduce the dose of lorazepam for women?

Doses should be reduced by 50% when coadministered with probenecid or valproate. INJECTION: It may be necessary to increase the dose in female patients who are concomitantly taking oral contraceptives. -Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.

What is the molecular formula for lorazepam injection?

The molecular weight is 321.16, and the C.A.S. No. is [846-49-1]. The structural formula is: Lorazepam is a nearly white powder almost insoluble in water. Each mL of sterile injection contains either 2.0 or 4.0 mg of lorazepam, 0.18 mL polyethylene glycol 400 in propylene glycol with 2.0% benzyl alcohol as preservative.