How is mesna given?

Mesna comes as a tablet to take by mouth. The first dose of mesna is usually given as an injection into your vein at the same time as you receive your chemotherapy treatment. After that, your doctor may choose to continue your treatment with mesna tablets.

How is ifosfamide administered?

Ifosfamide must also be given in combination with mesna to prevent hemorrhagic cystitis. Reconstitution, Powder for Injection: 1 g vial: Reconstitute with 20 mL, of sterile water for injection or bacteriostatic water for injection containing parabens or benzyl alcohol, for a concentration of 50 mg/mL.

When should mesna be given?

MESNA is given at the start and then after ifosfamide therapy. The usual dosing scheme is that the total dose of MESNA is 60% of the ifosfamide dose. It is given in 3 bolus doses of 20% of the ifosfamide dose at time 0 with the ifosfamide and then 4 and 8 hours later.

Does ifosfamide cause hair loss?

Temporary hair loss frequently occurs in patients using this drug. Normal hair growth should return after treatment has ended. Many people using this medication have serious side effects.

How do you give cyclophosphamide and mesna?

Where ifosfamide or cyclophosphamide is used as an iv bolus: Mesna is given by intravenous injection over 15-30 minutes at 20% of the simultaneously administered oxazaphosphorine on a weight for weight basis (w/w). The same dose of mesna is repeated after 4 and 8 hours.

Can you overdose on mesna?

There is no indicated antidote to mesna overdose. Mesna administration is usually via IV bolus or oral tablet, and therefore, unlike a drip, it cannot be immediately stopped with the appearance of adverse effects.

How long is ifosfamide infusion?

IFEX should be administered as a slow intravenous infusion lasting a minimum of 30 minutes. Other reference 2: Solutions diluted for administration are stable for 7 days at room temperature and for 6 weeks under refrigeration. Reconstituted solutions may be stored under refrigeration for up to 21 days.

Which side effects of ifosfamide limits its use as anticancer agent?

Although ifosfamide has several significant toxic effects, the dose-limiting toxicity is hemorrhagic cystitis. The high incidence of this toxicity requires uroprotection with aggressive hydration, frequent bladder emptying, and the concurrent use of mesna, a uroprotective agent.

When do you add mesna with cyclophosphamide?

Morning administration of cyclophosphamide is recommended, to decrease the amount of drug dwelling in the bladder overnight. Consider usage of mesna with high dose therapy of cyclophosphamide (>1 g/m2). Oral tablets should be administered as a single dose in the morning, with or without food.

What is ifosfamide toxicity?

Central nervous system (CNS) toxicity has been reported in approximately 10%–30% of patients receiving intravenous infusions of ifosfamide. Encephalopathy is a rare but serious CNS adverse reaction in these patients, and although usually transient and reversible, may cause persistent neurological dysfunction or death.

Can you give IV mesna orally?

Mesna can be mixed in the same infusion bag as the ifosfamide. Oral use of mesna ampoules: Mesna has been shown to be effective when taken orally.

How is the daily dose of Mesnex calculated?

MESNEX injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage weight by weight (w/w) at the time of ifosfamide administration and 4 and 8 hours after each dose of ifosfamide. The total daily dose of MESNEX is 60% of the ifosfamide dose. The recommended dosing schedule is outlined below in Table 1.

What is the dosage of ifosfamide for Mesnex injection?

MESNEX injection is given as intravenous bolus injections in a dosage equal to 20% of the ifosfamide dosage (w/w) at the time of ifosfamide administration. MESNEX tablets are given orally in a dosage equal to 40% of the ifosfamide dose 2 and 6 hours after each dose of ifosfamide.

How often should I take a daily dose of mesna?

Total daily mesna dosage is at least 60% of the ifosfamide dosage. For high-dose ifosfamide therapy, a mesna dose of 20% of the ifosfamide dosage IV has been administered 15 minutes before ifosfamide administration and then every 3 hours for 3 to 6 doses. A similar regimen may be used for high-dose cyclophosphamide therapy.

How much Mesnex should I drink a day?

Dosage is based on your body size and your dose of ifosfamide (or cyclophosphamide).While taking this medication, drink at least a quart (4 cups or 1 liter) of liquid each day unless directed otherwise by your doctor.