How is Elliptocytosis treated?
There is no treatment needed for the disorder unless severe anemia or anemia symptoms occur. Surgery to remove the spleen may decrease the rate of red blood cell damage.
How is hereditary elliptocytosis inherited?
Hereditary elliptocytosis is caused by a genetic change in either the EPB41, SPTA1, or SPTB gene, and is inherited in an autosomal dominant pattern. [15370] Hereditary pyropoikilocytosis is a related condition with more serious symptoms, and is inherited in an autosomal recessive pattern.
In which conditions can you see Elliptocytes?
Elliptocytes can occur in many other conditions (eg, iron deficiency, leukemias, megaloblastic anemias, myeloproliferative diseases, myelodysplastic syndromes) but usually do not reach the proportions observed in patients with HE.
How is Elliptocytosis diagnosed?
Hereditary elliptocytosis can be diagnosed by looking at the shape of the red blood cells under the microscope (blood smear). Genetic testing can help as well. Hereditary elliptocytosis is sometimes diagnosed by chance when other conditions are suspected.
Is hereditary Elliptocytosis extravascular hemolysis?
There is extravascular hemolysis in hereditary elliptocytosis, which is characterized by an increased reticulocyte count, increased lactate dehydrogenase, increased indirect bilirubin, and decreased haptoglobin level.
Can a thyroid patient donate platelets?
Thyroid disease Patients with thyroid disease may not donate if the condition is under investigation or if malignancy is suspected. Anyone on maintenance therapy with levothyroxine must be stabilised for at least three months before donation. An over- or an underactive thyroid increases the risk of heart disease.
What is the minimum hemoglobin required for blood donation?
12.5g/dL
To help ensure that it is safe for you to donate, females must have a minimum hemoglobin level of 12.5g/dL and males must have a minimum level of 13.0g/dL. A donor’s hemoglobin level cannot be higher than 20.0g/dL to donate.
In what condition can you see Elliptocytes?
What does it mean to have few elliptocytes?
Rare elliptocytes (less than 1%) on a peripheral blood smear are a normal finding. These abnormal red blood cells are seen in higher numbers in the blood films of patients with blood disorders such as: Hereditary elliptocytosis and Southeast Asian ovalocytosis. Thalassemia. Iron deficiency.
What does elliptocytosis stand for in medical terms?
el·lip·to·cy·to·sis. (ē-lip’tō-sī-tō’sis), A hematologic disorder in which 50-90% of the red blood cells consist of rod forms and elliptocytes; often associated with a hemolytic anemia.
What do you need to know about hereditary elliptocytosis?
Summary Summary. Hereditary elliptocytosis (HE) refers to a group of inherited blood conditions where the red blood cells are abnormally shaped.
What does it mean when your red blood cells are elliptical?
Hereditary elliptocytosis, also known as ovalocytosis, is an inherited blood disorder in which an abnormally large number of the patient’s erythrocytes (i.e. red blood cells) are elliptical rather than the typical biconcave disc shape. Such morphologically distinctive erythrocytes are sometimes referred to as elliptocytes or ovalocytes.
How does folate help with hereditary elliptocytosis?
Folate helps to reduce the extent of haemolysis in those with significant haemolysis due to hereditary elliptocytosis. Because the spleen breaks down old and worn-out blood cells, those individuals with more severe forms of hereditary elliptocytosis can have splenomegaly.
