How do mutator phenotypes occur?
Simply stated, cancer cells exhibit a mutator phenotype. This phenotype is the result of mutations in genes that function in the maintenance of genomic stability. It is manifested by increases in mutation rates and in genetic evolution of cancer cells that drives tumor progression.
What are 4 of the multiple intelligences?
In order to capture the full range of abilities and talents that people possess, Gardner theorizes that people do not have just an intellectual capacity, but have many kinds of intelligence, including musical, interpersonal, spatial-visual, and linguistic intelligences. …
What is the mutator phenotype hypothesis?
The mutator phenotype hypothesis states that normal mutation rates are insufficient to account for the multiple mutations observed in human tumors, and that cancer cells must therefore incur increased rates of mutagenesis.
What is the role of mutator gene?
‘Mutator’ genes increase the mutation rate throughout an organism’s genome by disrupting DNA repair functions.
What is the multiple intelligence theory explain?
Multiple intelligences is a theory first posited by Harvard developmental psychologist Howard Gardner in 1983 that suggests human intelligence can be differentiated into eight modalities: visual-spatial, verbal-linguistic, musical-rhythmic, logical-mathematical, interpersonal, intrapersonal, naturalistic and bodily- …
What are the different theories of intelligence?
Major theories include Sternberg’s triarchic theory, Gardner’s theory of multiple intelligences, and Piaget’s theory of development. Biological theories emphasize the relationship between intelligence, and the brain and its functions.
What is a mutator gene?
Medical Definition of mutator gene : a gene that increases the rate of mutation of one or more other genes. — called also mutator.
How is the mutator phenotype related to cancer?
The mutator phenotype hypothesis was postulated almost 40 years ago to reconcile the observation that while cancer cells display widespread mutational burden, acquisition of mutations in non-transformed cells is a rare event. Moreover, it also suggested that cancer evolution could be fostered by increased genome instability.
Why are there so many mutations in tumor cells?
We initially proposed that the multiple mutations found in tumor cells would result from mutations in genes that guarantee the fidelity of DNA synthesis or the adequacy of DNA repair (1) . Mutations in bacterial DNA polymerases were known to produce mutations throughout the genome (6) .
What are the different types of intelligence according to Gardner?
The eight kinds of intelligence Gardner described are: Visual-spatial intelligence. Verbal-linguistic intelligence. Bodily-kinesthetic intelligence. Logical-mathematical intelligence. Interpersonal intelligence. Musical intelligence. Intrapersonal intelligence.
How many different theories of intelligence are there?
Gardner proposed that the traditional idea of intelligence, based on IQ testing, did not fully and accurately depict a person’s abilities. His theory proposed eight different intelligences based on skills and abilities that are valued in different cultures: 5
