Does zosyn cause Aki?

If alternative treatment options are inadequate or unavailable, monitor renal function during treatment with Zosyn. Precautions section stating that combined use of these two drugs may be associated with an increased incidence of acute kidney injury.

Does zosyn cause nephrotoxicity?

Of course, it remains possible that piperacillin-tazobactam is nephrotoxic (e.g. perhaps in rare cases involving acute tubulointerstitial nephritis). Nonetheless, currently there isn’t clear evidence that piperacillin-tazobactam commonly exhibits true nephrotoxicity.

Can zosyn be given during dialysis?

Renal Impairment Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g ZOSYN (0.67 g piperacillin/0.08 g tazobactam) should be administered following each dialysis period on hemodialysis days. No additional dosage of ZOSYN is necessary for CAPD patients.

Does piperacillin-tazobactam cause Aki?

Recent studies have found that treatment with the combination of vancomycin and piperacillin-tazobactam (VPT) is associated with a 2-fold increase in the incidence of acute kidney injury (AKI) [2], occurring in 22.2% for VPT as opposed to 12.9% for other antibiotic combinations with vancomycin in a recent meta-analysis …

Is Piptaz safe in CKD?

Due to its potential nephrotoxicity (see section 4.8), piperacillin/tazobactam should be used with care in patients with renal impairment or in hemodialysis patients. Intravenous dosages and administration intervals should be adjusted to the degree of renal function impairment (see section 4.2).

Is ZOSYN removed by dialysis?

Since hemodialysis removes 30% to 40% of the administered dose, an additional dose of 0.75 g ZOSYN (0.67 g piperacillin/0.08 g tazobactam) should be administered following each dialysis period on hemodialysis days.

How is ZOSYN administered?

ZOSYN should be administered by intravenous infusion over 30 minutes. The usual total daily dose of ZOSYN for adults is 3.375 g every six hours totaling 13.5 g (12.0 g piperacillin/1.5 g tazobactam). The usual duration of ZOSYN treatment is from 7 to 10 days.

Can zosyn and vancomycin be given together?

vancomycin and zosyn through the same lumen concurrently if possible (i.e. administer vancomycin and zosyn infusion through separate lumens or try administering vancomycin prior to the zosyn 4-hour infusion).

Can piperacillin and tazobactam cause renal failure?

Tazobactam/piperacillin (TAZ/PIPC) is a combination antibiotic frequently used to treat pneumonia. It has recently been reported that TAZ/PIPC worsens renal function in patients with existing renal impairment.

Is azithromycin safe in renal failure?

Azithromycin is excreted in bile and then faeces. Unlike clarithromycin, very little unchanged azithromycin appears in the urine, and there are no biologically active metabolites. Thus, azithromycin dosing modification is not needed in patients with kidney disease.