Can you get CMV from transplant?

Sometimes a transplant patient can get CMV from the transplanted organ, bone marrow, or stem cells, or from blood or white blood cell transfusions given when they are sick.

How common is CMV in transplant patients?

The incidence of CMV is between 9 and 23% after heart transplantation, between 22 and 29% after liver transplantation and between 8 and 32% after kidney transplantation 7.

How is cytomegalovirus used to treat stem cell transplant?

Four antiviral drugs are used for preventing or treating CMV: ganciclovir, valganciclovir, foscarnet, and cidofovir. With prolonged and repeated use of these drugs, CMV can become resistant to standard therapy, resulting in increased morbidity and mortality, especially in HCT recipients.

Can CMV cause hepatitis?

Hepatitis has been commonly observed in patients with primary CMV infection and mononucleosis. levels of hepatocellular enzymes may be mildly and transiently increased, and, in rare cases, jaundice may develop.

Why do transplant patients develop CMV infection?

CMV is most often caused by a reactivation of CMV acquired long before your transplant. If you develop your first CMV infection, the virus likely came from your transplanted organ. (The donor might have been exposed to the virus.)

Can you get CMV virus twice?

Once CMV is in a person’s body, it stays there for life and can reactivate. A person can also be re-infected with a different strain (variety) of the virus.

How long does CMV IgG stay positive?

CMV IgM antibody in some women may remain positive for over 4 months (sometimes up to a year or more) or may be a false positive result. Therefore, a third CMV antibody test may be performed, called CMV IgG avidity index.

How is cytomegalovirus treated?

How is CMV hepatitis diagnosed?

The gold standard to confirm the diagnosis is the presence of CMV-specific antibodies type IgG and IgM in the (maternal) blood sample running an immunoassay or a polymerase chain reaction, which can be either qualitative or quantitative by measuring the amount of viral DNA in the respective sample[4, 5].

What is CMV hepatitis?

Overview. Cytomegalovirus (CMV) is a common virus. Once infected, your body retains the virus for life. Most people don’t know they have CMV because it rarely causes problems in healthy people. If you’re pregnant or if your immune system is weakened, CMV is cause for concern.