What is Crossed cerebellar diaschisis?

Crossed cerebellar diaschisis (CCD) describes a depression of oxidative metabolism glucose and blood flow in the cerebellum secondary to a supratentorial lesion in the contralateral cerebral hemisphere. PET/MR has the potential to become a powerful tool for demonstrating and imaging intracranial lesions .

Where do cortico cerebellar fibers Decussate?

The FPC fibers continue through the ventro-medial part of the cerebral peduncle (Fig. 5c) caudally to the level of the pons where they decussate (Figs. 3a, ​6b) and travel through the contralateral middle cerebellar peduncle (MCP) into the cerebellum (Fig.

What is meant by Diaschisis?

Diaschisis refers to the disruption in blood flow and metabolism in otherwise intact regions of the brain that are anatomically connected with the injured zone.

What is neuronal sprouting?

Definition. (cell biology) The process whereby a neuron generates additional branches (outgrowths) to establish new links between existing neurons.

Why is cerebellum ipsilateral?

Unlike the cerebral cortex, the cerebellum receives input from, and controls output to, the ipsilateral side of the body, and damage to the cerebellum therefore results in deficits to the ipsilateral side of the body.

What is dendritic arbor?

The dendritic arbor is a complex branching structure, which receives signals from thousands of other neurons and conducts them toward the cell body, where they are integrated.

Where do the tracts cross?

The lateral corticospinal tract neurons cross the midline at the level of the medulla oblongata, and controls the limbs and digits. The lateral tract forms about 90% of connections in the corticospinal tract; the vast majority cross over in the medulla, while the rest (about 2-3%) remain ipsilateral.

What does it mean to have crossed cerebellar diaschisis?

Crossed cerebellar diaschisis. Crossed cerebellar diaschisis refers to a depression in function, metabolism, and perfusion affecting a cerebellar hemisphere occurring as a result of a contralateral focal supratentorial lesion, classically an infarct.

What is the definition of diaschisis in the brain?

Diaschisis in the brain, by definition, refers to an acute inhibition of function and metabolism produced by a focal disturbance in a portion of the brain at a distance from the original site of injury but connected via white matter tracts 1.

What causes CCD in the contralateral cerebellar hemisphere?

While CCD is usually caused by an MCA stroke in the contralateral cerebral hemisphere, interruption of the corticopontocerebellar tract anywhere along its course can result in similar findings. In this case, midbrain surgery caused deafferentation of the contralateral cerebellar hemisphere.

Is the crossed cerebellar atrophy a reversible condition?

Although diaschisis is considered reversible, crossed cerebellar atrophy commonly develops after large destructive lesions of the contralateral cerebral hemisphere ( Figure 1 ). It seems this is due to transsynaptic degeneration rather than secondary to the decreased perfusion. Figure 1. Crossed cerebellar diaschisis.