What other diseases will cause elevation of alkaline phosphatase?
Bone pathology causes of elevated alkaline phosphatase include Paget’s disease, hyperparathyroidism, osteomalacia, metastatic bone disease and a recent fracture.
Is 154 high for alkaline phosphatase?
The normal range of alkaline phosphatase in the blood is 20 to 140U/L, although this can vary from lab to lab. Children and pregnant women can have significantly higher levels of the enzyme in their blood [1]. Values above 130 U/L are usually considered to be high.
When should you evaluate high alkaline phosphatase?
Initial evaluation of an isolated elevation of alkaline phosphatase (ALP) should include repeat testing to confirm elevation, and a history and physical examination to evaluate for causes such as malignancy, congestive heart failure, hyperthyroidism, and renal disease.
What medications cause high alkaline phosphatase?
Some examples of drugs that may cause a raised alkaline phosphatase include:
- Antibiotics: penicillin derivatives (1)
- Antiepileptic drugs: Carbamazepine.
- Antihistamines: Cetirizine (1)
- Cardiovascular drugs: Captopril (1)
- Disease modifying agents:
- Polycyclic aromatic hydrocarbons:
- Psychotropic drugs:
- Diabetes drugs:
What is a bad alkaline phosphatase level?
The normal range for serum ALP level is 20 to 140 IU/L , but this can vary from laboratory to laboratory. The normal range runs higher in children and decreases with age.
Can ibuprofen cause high alkaline phosphatase?
About 57 patients are investigated and were given several doses of ibuprofen. The main finding is an increase in ALP, as well as moderate to high elevation of SGPT and SGOT hepatic enzymes, but they remain around their normal ranges.
Can vitamin D reduce alkaline phosphatase?
A reduction in serum ALP was also seen in the euparathyroid subjects (2.4 +/- 0.77 to 2.2 +/- 0.64 mu kat/l, p = 0.03). This study indicates that treatment with active vitamin D is effective in reducing the increased bone turnover seen in subjects with both primary and secondary HPT.
What causes high Alk Phos?
High alk. Phos can be caused by any/many liver disorders from any cause including hepatitis, obstruction of the bile due to stone or tumor.
What does elevated ALP mean?
As ALP is most abundant in the bones and liver, elevated ALP levels are generally a sign of a liver or bone condition. An obstruction of the liver or damage to it will cause ALP levels to rise. This will also occur if there is an increase in bone cell activity.
What does elevated alkaline phosphatase tell you?
When the test results show that the patient has an elevated alkaline phosphatase, it means that either the liver is damaged or something is causing increased bone cell activity. ALP test does not tell which of the two (liver or bone) is causing increased ALP.
What does high Alk Phos mean?
A high alk phos level does not reflect liver damage or inflammation. A high alk phos level occurs when there is a blockage of flow in the biliary tract or a buildup of pressure in the liver–often caused by a gallstone or scarring in the bile ducts.
