What is the survival rate for large cell neuroendocrine carcinoma?

Large-cell neuroendocrine carcinoma (LCNEC) is a rare (only 2–3% of all primary lung cancers) and typically aggressive malignancy with poor prognosis [1]. The 5-year overall survival of patients diagnosed with LCNEC ranges from 15% to 57% [2,3,4,5].

Is LCNEC a Nsclc?

Large cell neuroendocrine carcinoma (LCNEC) is a rare pulmonary tumor, with features of both small cell lung carcinoma (SCLC) and non-small cell lung cancer (NSCLC). Due to the rarity of LCNEC, there are no large randomized trials that define the optimal treatment approach for either localized or advanced disease [1].

What are the characteristics of large cell carcinoma?

Histologically, large cell carcinomas consist of sheets and nests of large cells with vesicular nuclei, prominent nucleoli, and moderate or abundant amounts of cytoplasm. LCNECs demonstrate neuroendocrine architectural features and immunohistochemical or ultrastructural evidence of neuroendocrine differentiation.

Is high grade neuroendocrine carcinoma curable?

Neuroendocrine carcinomas (NECs), or high-grade, poorly-differentiated NETs, are the most aggressive subtype. Surgical resection remains the primary treatment modality and may be curative, thus early diagnosis is paramount.

What are most neuroendocrine tumors that account for approximately 20% of lung cancers?

Carcinoid Tumors. Pulmonary or bronchial carcinoid tumors account for over 25% of all carcinoid tumors and for 1%–2% of all pulmonary neoplasms (,4). About 10%–20% of pulmonary carcinoids are atypical carcinoids; the remaining 80%–90% are typical carcinoids (,5).

Do neuroendocrine tumors cause pain?

Neuroendocrine tumors don’t always cause signs and symptoms at first. The symptoms you might experience depend on the location of your tumor and whether it produces excess hormones. In general, neuroendocrine tumor signs and symptoms might include: Pain from a growing tumor.

Where is a neuroendocrine tumor located?

Neuroendocrine tumors are rare and can occur anywhere in the body. Most neuroendocrine tumors occur in the lungs, appendix, small intestine, rectum and pancreas.

Is large cell carcinoma the same as large cell neuroendocrine carcinoma?

Large cell neuroendocrine carcinoma (LCNEC) is a variant of large cell carcinoma (Travis et al., 1999). It is a high-grade non–small cell neuroendocrine carcinoma that differs from atypical carcinoid and small cell carcinoma (Travis et al., 1991, 1998).

How long can you live with large cell carcinoma?

Large cell carcinoma is a type of non-small cell lung cancer. Non-small cell lung cancer (NSCLC) makes up around 80–85% of lung cancers….Prognosis.

How aggressive are neuroendocrine tumors?

Large cell neuroendocrine tumours tend to be aggressive tumours that grow quickly. They are more likely to spread to other parts of the body. Small cell lung neuroendocrine carcinomas, or small cell lung cancers, are also poorly differentiated cancerous tumours.