What type of disease is Charcot-Marie-Tooth?

Charcot-Marie-Tooth (CMT) disease is an inherited nerve problem. It causes abnormalities in the nerves that supply your feet, legs, hands, and arms. It affects both your motor and sensory nerves. Motor nerves carry signals from your brain to your muscles, telling them to move.

Is Charcot-Marie-Tooth disease an autoimmune disease?

Herein we report that mutations in this gene lead to an extended and more complex syndrome than previously recognized. The phenotypic features encompasses neurological alterations similar to those observed in the axonal type 2 form of Charcot-Marie-Tooth disease (CMT2) and include autoimmune manifestations.

Is Charcot foot and Charcot-Marie-Tooth?

Charcot foot in its original sense is equivalent to stage 4 of hereditary motor and sensory neuropathy (HMSN) which is known as Charcot-Marie-Tooth disease since 1886. This entity, which can be subdivided into 3 groups including subgroups, predominantly begins during childhood and progresses slowly.

Is Charcot-Marie-Tooth the same as Charcot arthropathy?

Charcot neuropathic arthropathy (also known as a Charcot joint, neuropathic joint or Charcot neuro/osteoarthropathy) refers to a progressive destructive joint and surrounding bone disorder in patients with abnormal pain sensation and proprioception [1,2].

Is Charcot-Marie-Tooth an inflammatory disease?

Charcot-Marie-Tooth Disease Type 1A and Inflammatory-Demyelinating Lesions in the Central Nervous System.

Can CMT affect your eyes?

In CMT Type 6 symptoms can start either in early childhood, teenage years or adulthood. CMT Type 6 involves development of optic atrophy with loss of vision or blindness, muscle atrophy and weakness, loss of sensation, and balance and gait difficulties.

When do symptoms of Charcot Marie Tooth disease appear?

Symptoms usually begin in your feet and legs, but they may eventually affect your hands and arms. Symptoms of Charcot-Marie-Tooth disease typically appear in adolescence or early adulthood, but may also develop in midlife. Signs and symptoms of Charcot-Marie-Tooth disease may include: Difficulty lifting your foot at the ankle (footdrop)

Are there any medications that can make Charcot Marie Tooth disease worse?

Also, medications such as the chemotherapy drugs vincristine (Marqibo), paclitaxel (Abraxane, Taxol) and others can make symptoms worse. Be sure to let your doctor know about all of the medications you’re taking. Complications of Charcot-Marie-Tooth disease vary in severity from person to person.

Which is the most common type of foot deformity?

For example, as muscles that lift the foot at the ankle become weak, muscles that lower and curl the foot downward contract and tighten, causing the most common type of foot deformity — a shortened foot with a pes cavus. As the contracture gets worse, the toes can become locked in a flexed position.

What happens to your feet when you have CMT?

Foot contractures resulting in high-arched feet often occur in CMT. Contractures and bone deformities. As the contracture gets worse, the toes can become locked in a flexed position. A small fraction of people with CMT develop “flat feet” (pes planus), presumably because of a different pattern of muscle weakness.