What are directly compressible diluents?
a. Direct compressible excipients prepared by chemical modification include Ethyl Cellulose, Methyl Cellulose, Hydroxypropyl Methylcellulose and Sodium Carboxymethyl Cellulose prepared from cellulose, Cyclodextrin prepared from starch, Lactitol from lactose etc.
What are directly compressible excipients?
Directly compressible excipients are the speciality products produced by patented spray drying, fluid bed drying, roller drying or co-crystallization. Hence, the products are relatively costly than the respective raw materials.
What are directly compressible vehicle?
Vishal Shelke. These are the diluents or fillers designed to make up the required bulk of the tablets. These are inactive ingredients that are added to tablets in addition to the active drug.
What do you mean by direct compression?
The term “direct compression” is defined as the process by which tablets are compressed directly from powder mixture of API and suitable excipients. No pretreatment of the powder blend by wet or dry granulation procedure is required.
Why is diluent used in tablet formulation?
Diluents are also very important in the pharmaceutical industry. They are inactive ingredients that are added to tablets and capsules in addition to the active drug. These additives may be used as binders, disintegrants (help the tablet break apart in the digestive system), or flavor enhancers.
What is primogel?
Description. Primojel® Sodium starch glycolate is a superdisintegrant suitable for a variety of tablet and capsule formulations. In higher concentrations, Primojel® can act as a dissolution enhancing agent. Primojel® is highly effective when used intragranular and/or extragranular in granular formulations.
What is mechanical strength of tablet?
The mechanical strength of the tablets has been determined with a three-point bending test and by applying a diametral load across the edges of the tablets with platens of different designs. Many of the tablets tested in three-point bending did not fail in tension.
Why is direct compression used?
Direct compression is a popular choice because it provides the shortest, most effective and least complex way to produce tablets. The manufacturer can blend an API with the excipient and the lubricant, followed by compression, which makes the product easy to process.
What is direct compression used for?
Today, the term direct compression (or direct compaction) is used to define the process by which tablets are compressed directly from powdered active drug substance and suitable excipients into a firm compact without employing the process of granulation.
Why are diluents used?
What do diluents do?
Diluents are used to increase the bulk volume of solid oral dosage forms such as tablets and capsules. They help one to facilitate handling of dosage form and to achieve targeted content uniformity.
How is sodium starch glycolate made?
Sodium starch glycolate is a commonly used super-disintegrant employed to promote rapid disintegration and dissolution of IR solid dosage forms. It is manufactured by chemical modification of starch, i.e., carboxymethylation to enhance hydrophilicity and cross-linking to reduce solubility.
How are direct compressible diluents classified by Wells and Langridge?
According to Wells and Langridge, direct compressible diluents may be classified based on their disintegration and flow properties into
What are some examples of direct compression excipients?
Other direct compressible excipients such as microcrystalline cellulose (the first effective dry filler and binder), Starch 1500 (a compressible starch which maintains its disintegrant properties), Emcompress (a free-flowing dicalcium phosphate) and a number of direct compression sugars also appeared in the pharmaceutical market.
What are the properties of a direct compression blend?
It should have a particle size range which should be equivalent to most active ingredients. It should have a good pressure hardness profile. A direct compression blend should also possess an optimum bulk density and it should be acceptable.
How is microcrystalline cellulose used in direct compression?
Microcrystalline cellulose is used in direct compression as a strong dry binder, tablet disintegrants, an absorbent, a lubricant, and anti-adherent. It is also used as a diluent in tablets prepared by wet granulation, as filler in capsules and for the production of spheres.
