What is mesoporous silica nanoparticles?
Mesoporous silica nanoparticles (MSNs) are one of the most well-studied inorganic nanoparticles for the delivery of drugs and contrast agents. In order to deliver nucleic acid agents, the silica surface of the MSNs is converted to carry positive charges for the binding of DNA or siRNA.
How do you make mesoporous silica nanoparticles?
Mesoporous silica nanoparticles (MSNs) have been prepared by sol–gel process, using tetraethyl orthosilicate (TEOS) as alkoxide precursor and cetyltrimethylammonium bromide (CTAB) as surfactant.
What is a silica sphere?
Silica spheres are manufactured using proprietary technologies which allow the essential properties of amorphous silica to be maintained while simultaneously achieving controlled spherical shape and uniform particle size. Untreated silica spheres are typically hydrophilic and negatively charged.
Are mesoporous silica nanoparticles biodegradable?
Mesoporous silica nanoparticles have been extensively explored in anticancer nanomedicine due to their excellent biodegradability, which is one important focus in their further clinical translations.
What are mesoporous silica nanoparticles used for?
Mesoporous silica nanoparticles can be used as host materials for transporting therapeutics medicaments or encapsulation of molecules due to their biocompatibility, high loading capacity, the capability to attach target ligands for specific cellular recognition, or the design of well-defined and tuneable porosity (Tang …
What is silica nanoparticles used for?
Silica (silicon dioxide) nanoparticles facilitate surface properties such as geometry and porosity to be utilized in therapeutics and diagnostic fields. Silica nanoparticles can deliver hydrophilic drugs to target tissues.
How do you synthesis mesoporous silica?
The synthesis process of mesoporous silica nanoparticles (MSNPs) using the sol–gel method. (A) The surfactant (CTAB) is dissolved in water. (B) Silica precursor is then added dropwise and condensed around the surfactant template. (C) The sol–gel occurs, and silica NPs are produced.
Is silica microsphere natural?
Silica Microspheres has a rating of 4.8 stars based on 47 reviews. If you haven’t tried working with silica in your formulary yet, we encourage you to sample some. It really improves the performance and feel of the product and it is a very natural addition to the ingredients list.
What are mesoporous silica materials?
Mesoporous silica nanoparticles are synthesized by reacting tetraethyl orthosilicate with a template made of micellar rods. The result is a collection of nano-sized spheres or rods that are filled with a regular arrangement of pores. The template can then be removed by washing with a solvent adjusted to the proper pH.
What is the application of magnetic mesoporous silica nanoparticles MMSN )?
Recently, magnetic mesoporous silica nanoparticles (MSNs) have been considered for biomedical applications because they possess unique properties including biocompatibility, magnetic properties, high surface area, high loading capability, tunable porosity and surface functionalization.
What are silica particles?
Colloidal silica (silicon dioxide) nanoparticles are amorphous materials and are generally spherical in shape. They can be made to have a broad range of sizes and their surface chemistry easily modified to target a variety of applications.
How is mesoporous silica prepared in water phase?
Spherical mesoporous silica particles with tunable pore size and tunable outer particle diameter in the nanometer range were successfully prepared in a water/oil phase using organic templates method. This method involves the simultaneous hydrolytic condensation of tetraorthosilicate to form silica and polymerization of styrene into polystyrene.
How big is the pore of a mesoporous particle?
Interestingly, unlike common mesoporous materials, the particle with controllable pore size (4–15 nm) and particle diameter (20–80 nm) were produced using the method described herein. The ability to control pore size was drastically altered by the styrene concentration.
How big is a porous SIO 2 particle?
Submicrometer porous SiO 2 particles have a spherical shape and a narrow size distribution. Submicrometer spherical micro-mesoporous SiO 2 particles have been synthesized with a Brunauer–Emmett–Teller specific surface area of up to 1600 m 2 g −1, comparable with that of nanoporous carbon materials.
How to make silica particles bigger than 100 nm?
However, bigger silica particles were produced, with an outer size larger than 100 nm. In the experimental procedure, first, a mixed solution was prepared by dissolving and heating 0.1 g CTAB in 30 ml of aqueous solution at 60 °C in three-necked flask reactor.
