What is the A1 Milano gene?
Apolipoprotein A-1 Milano (also ETC-216, now MDCO-216) is a naturally occurring mutated variant of the apolipoprotein A1 protein found in human HDL, the lipoprotein particle that carries cholesterol from tissues to the liver and is associated with protection against cardiovascular disease.
Is apolipoprotein AI Milano good?
The mutant apolipoprotein A-I(Milano) has been associated with a reduced incidence of coronary disease in carriers. Furthermore, recombinant apolipoprotein A-I(Milano) has displayed remarkable atheroprotective activities and the possibility of directly reducing the burden of atherosclerosis in experimental models.
What type of mutation is apolipoprotein AI Milano?
Apolipoprotein A-I Milano (apoA-IMilano) is a naturally occurring human mutation of wild-type apolipoprotein A-I (apoA-IWT) having cystine substituted for arginine173. Two molecules of apo-IWT form disks with phospholipid having a defined relationship between the apoA-IWT molecules.
What is the function of Apo A1?
Normal Function The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body’s tissues to the liver.
Is HDL a cholesterol?
HDL (high-density lipoprotein), or “good” cholesterol, absorbs cholesterol and carries it back to the liver. The liver then flushes it from the body. High levels of HDL cholesterol can lower your risk for heart disease and stroke.
How is apolipoprotein AI Milano caused?
ApoA1-M is formed as a result of arginine 173 to cysteine substitution, conferring antithrombotic effects, and protection from cardiovascular diseases. Recombinant ApoA1-M has been formulated as a complex with phospholipids to mimic the properties of nascent HDL.
What is Apo A?
Apolipoprotein A is a protein carried in HDL (“good”) cholesterol. It helps start the process for HDL to remove bad types of cholesterol from your body. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease.
How do I keep my HDL high?
5 Ways to Raise Your HDL Cholesterol
- Get active. Physical activity can boost your HDL level.
- Lose extra weight. If you’re overweight, losing extra pounds can help raise your HDL levels, as well as cut your LDL (“bad”) cholesterol levels.
- Choose better fats.
- Alcohol in moderation.
- Stop smoking.
How can I increase my apolipoprotein?
Increasing Apolipoprotein B Studies suggest that alcohol decreases ApoB levels, likely due to its effect on the liver. Reducing alcohol consumption may help raise ApoB levels by improving liver health. In a study of 16 people, those who drank alcohol saw a decrease in their LDL-apoB levels [28].
