Which drugs are protein kinase inhibitors?

Protein Kinase Inhibitors

What does S6 kinase do?

The p70 ribosomal S6 kinase (S6K) family is a group of highly conserved kinases in eukaryotes that regulates cell growth, cell proliferation, and stress response via modulating protein synthesis and ribosomal biogenesis.

What is a specific kinase inhibitor?

The kinase inhibitors are a large group of unique and potent antineoplastic agents which specifically target protein kinases that are altered in cancer cells and that account for some of their abnormal growth.

What activates S6K?

In the classical insulin signaling pathway, S6K is activated by mTOR at the downstream of PI3K/Akt. The activation involves in S6K phosphorylation at T389 by mTOR, which enhances protein synthesis through phosphorylation of ribosomal protein S6 by S6K.

What is S6K in biology?

S6K is a serine/threonine kinase that is a member of the ribosomal S6 kinase (RSK) family. S6K exists in two main isoforms, S6K1 and S6K2, which can also be alternatively spliced to produce different splice forms.

What are the side effects of tyrosine kinase inhibitors?

Side Effects of Tyrosine Kinase Inhibitor (TKI) Therapy

• Nausea, vomiting and diarrhea.
• Muscle cramps and bone pain.
• Fatigue.
• Rashes.

Is gefitinib a chemotherapy?

Gefitinib is associated with less fatigue, myelosuppression and nausea than chemotherapy (but produces more skin rash, diarrhea and pneumonitis). Patients receiving gefitinib have improved quality-of-life compared to those receiving chemotherapy, making it an appropriate first-line choice.

What does ribosomal protein S6 mean?

Ribosomal Protein S6 A ribosomal protein that may play a role in controlling cell growth and proliferation. It is a major substrate of RIBOSOMAL PROTEIN S6 KINASES and plays a role in regulating the translation (TRANSLATION, GENETIC) of RNAs that contain an RNA 5′ TERMINAL OLIGOPYRIMIDINE SEQUENCE.

Are ribosomes associated with protein synthesis?

Ribosomes are minute particles consisting of RNA and associated proteins that function to synthesize proteins. Proteins are needed for many cellular functions such as repairing damage or directing chemical processes. Ribosomes can be found floating within the cytoplasm or attached to the endoplasmic reticulum.

Where does ribosomal protein synthesis take place?

Ribosomal proteins are synthesized in the cytoplasm and transported to the nucleus for subassembly in the nucleolus. The subunits are then returned to the cytoplasm for final assembly.

Is ribose a protein?

Ribose is a 5-carbon sugar that begins the metabolic process for the production of adenosine triphosphate (ATP), the major source of energy used by cells for building muscle tissue and normal function.* Ribose is also very important for metabolizing protein.