What does high GFAP mean?

In the healthy human brain, GFAP is mainly expressed in mature astrocytes (Middeldorp & Hol, 2011). Therefore, in clinical as well as fundamental experimental settings, high GFAP expression is believed to mark more differentiated, less malignant tumors.

What does GFAP stain for?

Immunoperoxidase staining for GFAP produces intense cytoplasmic staining of astrocytes, glial cells, and ependymal cells in normal brain. In neoplastic tissues, GFAP is useful for the identification of glial tumors such as astrocytomas and ependymomas.

What is GFAP in astrocytes?

Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes have a range of control and homeostatic functions in health and disease.

What does the medical term GFAP mean?

Glial fibrillary acidic protein
GFAP: Glial fibrillary acidic protein. The degenerative brain condition called Alexander disease is caused by mutation in GFAP (glial fibrillary acidic protein). Astrocytes are star-shaped cells that support the functions of nerve cells in the brain and spinal cord (central nervous system).

Where is GFAP expressed in the brain?

astrocyte cells
GFAP is expressed in the central nervous system in astrocyte cells. It is involved in many important CNS processes, including cell communication and the functioning of the blood brain barrier.

What cell component is GFAP?

The glial fibrillary acidic protein (GFA protein or GFAP) is the major protein constituent of glial intermediate filaments in differentiated fibrous and protoplasmic astrocytes of the central nervous system.

What is GFAP encephalitis?

Glial fibrillary acidic protein (GFAP) astrocytopathy is a newly proposed autoimmune neurologic syndrome characterized by meningitis, encephalitis, or myelitis associated with immunoglobulin G (IgG) antibodies to GFAP.