What is anti asialo-GM1?
Asialo-GM1 is a GM1 derivative without a sialic acid group. It is expressed on NK cells, basophils, monocytes/macrophages, and T cells. Antibodies specific for Asialo-GM1 are elevated in dementia, lupus, and Guillain-Barré syndrome.
What is asialo ganglioside?
Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) and the neutral glycolipid, asialo-GM1 are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy.
How do you deplete NK cells in mice?
Virus infections and in vivo cell depletion. To selectively deplete NK cells, mice were injected intraperitoneally (i.p.) once or twice with 25 μg of anti-NK1.
What are GM1 antibodies?
Ganglioside antibodies are associated with diverse peripheral neuropathies. Elevated antibody levels to ganglioside-monosialic acid (GM1) are associated with motor or sensorimotor neuropathies, particularly multifocal motor neuropathy. Anti-GM1 may occur as IgM (polyclonal or monoclonal) or IgG antibodies.
What is Miller Fisher syndrome?
Miller Fisher syndrome is a rare, acquired nerve disease that is considered to be a variant of Guillain-Barré syndrome. It is characterized by abnormal muscle coordination, paralysis of the eye muscles, and absence of the tendon reflexes. Like Guillain-Barré syndrome, symptoms may be preceded by a viral illness.
What is GM1?
GM1 gangliosidosis, also called beta-galactosidase-1 deficiency, is a genetic disorder that progressively destroys nerve cells in the brain and spinal cord.
What is motor neuropathy?
Multifocal motor neuropathy (MMN) is a disease that affects your body’s motor nerves. Those are the nerves that control your muscles. The condition makes it hard for them to send the electrical signals that move your body, which makes your hands and arms feel weak.
Does Guillain Barre cause anxiety?
In the acute phase of GBS, patients experience moderate-to-severe anxiety from the onset of muscle weakness to the initiation of treatment with plasmapheresis or IV Ig. Of the most severely disabled patients, 82% suffer with anxiety.
How is GM1 diagnosed?
A diagnosis of GM1 gangliosidosis (GM1), can be made by either enzyme analysis of the beta-galactosidase enzyme, or by molecular genetic testing of the GLB1 gene .
Can motor neuropathy reversed?
If the underlying cause of the neuropathy can be treated and cured (such as neuropathy caused by a vitamin deficiency), it’s possible that the neuropathy can be reversed too. However, frequently by the time individuals are diagnosed with a neuropathy, there is some degree of permanent damage that can’t be fixed.
How are anti asialo GM1 antibodies used in cancer research?
The glycolipid asialo ganglioside-GM1 (ASGM1) is expressed by T cells in viral infection and by natural killer (NK) cells. ASGM1 is localized in lipid raft structures in NK and CD8(+) T cells. Anti asialo GM1 antibody reduces natural killer (NK) activity in cells of various strains of mice and rats.
Where is asialo ganglioside-GM1 expressed in the body?
The glycolipid asialo ganglioside-GM1 (ASGM1) is expressed by T cells in viral infection and by natural killer (NK) cells. ASGM1 is localized in lipid raft structures in NK and CD8 (+) T cells.
Which is the most specific antibody for GM1?
Ten patients had the motor variant of CIDP without conduction block and three had elevated titers. Anti-IgM asialo GM1 antibodies had the highest sensitivity and specificity. High-titer IgM antibodies against monosialo GM1 occurred only in patients with various forms of pure motor neuropathy (100% specificity).
Which is anti-asgm1 antibody depletes NK cells?
Anti-ASGM1-mediated basophil depletion was operative as for NK cell depletion in various mouse strains, irrespective of NK1 allotype and MHC H2 haplotype, including C57BL/6, BALB/c, C3H, and A/J mice.
