What is the route for nitroglycerin?
Nitroglycerin comes as a sublingual tablet to take under the tongue. The tablets is usually taken as needed, either 5 to 10 minutes before activities that may cause attacks of angina or at the first sign of an attack.
What is the mechanism of action of nitroglycerin with regards to chest pain?
Mechanism of Action As with other nitrates used to treat anginal chest pain, nitroglycerin converts to nitric oxide (NO) in the body. NO then activates the enzyme guanylyl cyclase, which converts guanosine triphosphate (GTP) to guanosine 3′,5′-monophosphate (cGMP) in vascular smooth muscle and other tissues.
What is the mechanism of action of the drug nitroglycerin during angina pectoris?
The Mechanism of Action of Nitroglycerin in the Relief of Angina Pectoris: Reduction of Myocardial Oxygen Requirements by Extracoronary Vasodilation and Its Attenuation by the Chronic Administration of lsosorbide Dinitrate.
Can nitroglycerin be given IV?
Initially, 0.25 to 0.5 mcg/kg/minute continuous IV infusion. Titrate by 1 mcg/kg/minute IV every 15 to 20 minutes as tolerated. The usual dosage range is 1 to 5 mcg/kg/minute.
What is the mechanism of action for Nitro Dur?
Nitroglycerin causes the veins (vessels that return blood to the heart) to relax so that the work load of the heart is reduced. This lowers the heart’s oxygen needs. As a result, the heart muscle is well nourished and the frequency of angina attacks is reduced. NITRO-DUR is applied directly to the skin.
What is nitro drip?
Nitroglycerin injection is used to treat hypertension (high blood pressure) during surgery or to control congestive heart failure in patients who have had a heart attack. It may also be used to produce hypotension (low blood pressure) during surgery.
Which of the following is the beneficial action of nitroglycerin?
Nitroglycerin remains a first-line treatment for angina pectoris and acute myocardial infarction. Nitroglycerin achieves its benefit by giving rise to nitric oxide, which causes vasodilation and increases blood flow to the myocardium.
What precautions are taken when administering nitroglycerin?
Nitroglycerin sublingual tablets should not be chewed, crushed, or swallowed. They work much faster when absorbed through the lining of the mouth. Place the tablet under the tongue or between the cheek and gum, and let it dissolve. Do not eat, drink, smoke, or use chewing tobacco while a tablet is dissolving.
Where do you put a nitro patch on your body?
Usually, you will wear the patch on the upper arm or chest. However, you can wear it anywhere on the body below the neck and above the knees or elbows. Apply the patch to a clean, dry, and hairless area.
What is the mode of action for nitroglycerin?
The principal pharmacological action of nitroglycerin is relaxation of vascular smooth muscle. Although venous effects predominate, nitroglycerin produces, in a dose-related manner, dilation of both arterial and venous beds. Dilation of postcapillary vessels, including large veins, promotes peripheral pooling of blood,…
What is nitroglycerin tab?
Nitroglycerin sublingual tablets are used to treat episodes of angina (chest pain) in people who have coronary artery disease (narrowing of the blood vessels that supply blood to the heart). It is also used just before activities that may cause episodes of angina in order to prevent the angina from occurring.
How does nitroglycerin medication work?
Nitroglycerin belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load.
What is a nitroglycerin pill?
The nitroglycerin tablet ( Nitrostat ®) is a prescription drug approved for treating attacks of angina pectoris associated with coronary artery disease.
