How quickly does CMT progress?

Depending on the type of CMT, onset can be from birth to adulthood, and progression is typically slow. CMT usually isn’t life-threatening, and it rarely affects the brain.

When is orthopedic surgery needed for CMT?

2, 3 Orthopedic surgery is frequently required for CMT patients to correct severe foot deformities. The goals of surgical intervention for patients with CMT are to obtain a plantigrade foot and to correct the bony deformities and muscle imbalance.

What is life expectancy with Charcot-Marie-Tooth disease?

CMT isn’t usually life-threatening and rarely affects muscles involved in vital functions like breathing. People with most forms of CMT have a normal life expectancy.

How does Charcot Marie Tooth effect the body?

Charcot-Marie-Tooth disease (CMT) is one of a group of disorders that cause damage to the peripheral nerves -the nerves that transmit information and signals from the brain and spinal cord to and from the rest of the body, as well as sensory information such as touch back to the spinal cord and brain. CMT can also directly affect the nerves that control the muscles.

How many genes cause Charcot Marie Tooth disease?

Charcot-Marie-Tooth (CMT) neuropathies belong to the most common neurogenetic disorders. To date, mutations in more than 40 genes are known to be able to cause CMT. This genetic heterogeneity is a challenge for genetic diagnostics.

Does Charcot Marie Tooth affect the brain?

Charcot-Marie-Tooth Disease affects the nerves outside the spinal cord and brain. People with the condition can have problems with their feet and trouble balancing. Three doctors — Jean-Martin Charcot, Pierre Marie and Howard Henry Tooth – identified a nerve disease back in 1886.

How common is Charcot Marie Tooth disease?

Charcot-Marie-Tooth disease is the most common inherited disorder that involves the peripheral nerves, affecting an estimated 150,000 people in the United States. It occurs in populations worldwide with a prevalence of about 1 in 3,300 individuals.