What is the pKa of benzimidazole?

12.8
Benzimidazole

What is benzimidazole derivative?

Benzimidazole derivatives act by interfering with metabolic pathways. This compound is the most potent of a series of substituted 2-amino derivatives, is active against a wide variety of animal nematodes [41].

What is the use of benzimidazole?

Abstract:Benzimidazole and its derivatives are regarded as an important heterocyclic motif that exhibits a wide range of pharmaceutical applications including anticancers, antihypertensives, antivirals, antifungals, anti-HIVs, anti-convulsants, and anti-diabetics.

What are examples of benzimidazole?

Those of interest are mebendazole, flubendazole, fenbendazole, oxfendazole, oxibendazole, albendazole, albendazole sulfoxide, thiabendazole, thiophanate, febantel, netobimin, and triclabendazole.

What type of reaction mechanism is benzimidazole?

Principle: The two Carbon-nitrogen bonds in benzimidazole when disconnected give o-phenylenediamine and formic acid. Therefore, synthesis of benziemidazole is affected by simply heating the o-phenylenediamine and formic acid together (condensation type of reaction).

Which is the category of benzimidazole?

This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).

Which is commonly used benzimidazole?

Benzimidazole Derivatives

Is benzimidazole aromatic?

ABSTRACT: Benzimidazole is a heterocyclic aromatic organic compound containing nitrogen. This bicyclic compound is formed by the fusion of benzene with imidazole ring.

Is albendazole a benzimidazole?

Albendazole is a derivative of benzimidazole carbamate and is structurally related to mebendazole. Due to its greater bioavailability compared with mebendazole, it has become the preferred drug.

What are the reagents are needed benzimidazole?

Typical Procedure for the Preparation of Benzimidazoles A mixture of o-phenylenediamine (1 mmol), 4-chlorobenzaldehyde (1.1 mmol), and H2O2 (30%, 3 mmol), and PVP- TfOH (0. 2 g) was stirred magnetically for 6 min at 70 °C, and the progress of the reaction was monitored by TLC.

Is benzimidazole polar?

Conversely, the introduction of polar groupings into the molecule increases solubility in polar solvents. Benzimidazole distills unchanged above 300 ̊C. Benzimidazoles are weakly basic, being somewhat less basic than the imidazoles and are in general soluble in dilute acids.

What is benzimidazole Horse Wormer?

The benzimidazoles are a large chemical family used to treat nematode and trematode infections in domestic animals. Netobimin, albendazole, and triclabendazole are also active against liver flukes; however, unlike all the other benzimidazoles, triclabendazole has no activity against roundworms.

What does benzimidazole pKa of 5.3 mean?

According to a classification scheme(3), this estimated Koc value suggests that benzimidazole is expected to have high mobility in neutral and basic soils. Benzimidazole’s pKa of 5.3(4) indicates that it will be in the protonated form in acidic environments, and will tend to adsorb to soil particles and clays.

What happens to benzimidazole at low pHs?

At low pHs, when benzimidazole (pKa = 5.3 (8)) exists in a primarily protonated form, it is expected to adsorb to suspended solids and sediments. Volatilization from water surfaces is not expected (3) based upon an estimated Henry’s Law constant of 3.7X10-7 atm-cu m/mole (4).

What kind of compound is benzimidazole made of?

Benzimidazole is a heterocyclic aromatic organic compound. This bicyclic compound consists of the fusion of benzene and imidazole. It is a colorless solid.

What kind of ring system is benzimidazole used for?

Benzimidazole derivatives are among the top frequently used ring systems for small molecule drugs listed by the US FDA. In printed circuit board manufacturing, benzimidazole can be used as an organic solderability preservative.