Is Sodium Phenobarbital an acid or base?
Phenobarbital (5-ethyl-5-phenylbarbituric acid) is a weak acid with a molecular weight of 232.23 and low water solubility.
Is phenobarbital a weak acid or base?
Phenobarbital is an unionized acid with a pKa of 7.4, and, therefore, the conjugate base is anionic. The patient’s urinary pH is 5.4.
Is phenobarbital a sodium?
Phenobarbital sodium is a barbiturate that is the sodium salt of phenobarbital (barbituric acid substituted at C-5 by ethyl and phenyl groups). It is an organic sodium salt and a member of barbiturates. It contains a phenobarbital. Sodium phenobarbital is an odorless white crystalline powder.
What chemical class does phenobarbital belong to?
Phenobarbital belongs to a class of drugs known as barbiturate anticonvulsants/hypnotics.
What is phenobarbital sodium used for?
Phenobarbital is a prescription medicine used to treat and prevent the symptoms of seizures, sedation, hypnotics, Insomina and Status Epilepticus. Phenobarbital may be used alone or with other medications. Phenobarbital belongs to a class of drugs called Anticonvulsants, Barbiturates.
What is the pH of phenobarbital?
Phenobarbital’s pKa (−log of the dissociation constant − Ka) is similar to that of the physiologic blood pH, and therefore phenobarbital is 50% ionized and 50% nonionized at pH = 7.3, but the ratio of ionized to nonionized phenobarbital changes according to the physiologic pH (Anderson & Levy, 1995).
Why is phenobarbital an acid?
Phenobarbital is a long-acting barbituric acid derivative with antipsychotic property. Phenobarbital binds to and activates the gamma-aminobutyric acid (GABA)-A receptor, thereby mimicking the inhibitory actions of GABA in the brain.
How can you tell if a drug is an acid or base?
The only sure way to know whether a drug is acidic or basic is to learn the functional groups that confer acidity and basicity on a molecule. This should be done even if it means learning the names of the functional groups the way you learned multiplication tables at primary school.
Is phenobarbital sodium water soluble?
Solubility: Soluble in water (1 g/ml) or ethanol (100 mg/ml). Disposal: Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. This product is controlled by the Drug Enforcement Administration.
How is phenobarbital influenced by pH?
Is phenobarbital an agonist?
Phenobarbital, a gamma-amino butyric acid receptor agonist, can be used as a first-line medication as well as an adjunct medication in NAS treatment.
What type of seizure is phenobarbital used for?
Phenobarbital is approved in the United States by the Food and Drug Administration (FDA) for add-on therapy for partial and tonic-clonic seizures. It has been used alone for more than 80 years, however, to treat partial and tonic-clonic seizures. It is also used for treatment of status epilepticus.
Which is the organic salt of phenobarbital acid?
Phenobarbital sodium is a barbiturate that is the sodium salt of phenobarbital ( barbituric acid substituted at C-5 by ethyl and phenyl groups). It is an organic sodium salt and a member of barbiturates. It contains a phenobarbital.
How does phenobarbital work in the central nervous system?
Phenobarbital is a barbituric acid derivative that acts as a nonselective central nervous system depressant. It potentiates GAMMA-AMINOBUTYRIC ACID action on GABA-A RECEPTORS, and modulates chloride currents through receptor channels. It also inhibits glutamate induced depolarizations.
How much is the molecular weight of phenobarbital?
Phenobarbital PubChem CID 4763 Synonyms phenobarbital Phenobarbitone Phenobarbit Molecular Weight 232.23 Date s Modify 2021-06-26 Create 2005-03-25
What kind of taste does phenobarbital have?
Sodium phenobarbital is an odorless white crystalline powder. Aqueous solutions are alkaline to litmus and phenolphthalein (pH approximately 9.3). Bitter taste. A narcotic.
